Your browser doesn't support javascript.
loading
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Diagnosis and Management of Pediatric Acute Liver Failure.
Squires, James E; Alonso, Estella M; Ibrahim, Samar H; Kasper, Vania; Kehar, Mohit; Martinez, Mercedes; Squires, Robert H.
Afiliação
  • Squires JE; Division of Gastroenterology, Hepatology and Nutrition, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
  • Alonso EM; Department Pediatric Hepatology, Ann and Robert H Lurie Children's Hospital, Chicago, Illinois, USA.
  • Ibrahim SH; Department of Pediatrics, Division of Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
  • Kasper V; Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children's Hospital, Providence, RI.
  • Kehar M; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
  • Martinez M; Department of Pediatrics, Vagelos College of Physician and Surgeons, Columbia University, New York, NY.
  • Squires RH; Division of Gastroenterology, Hepatology and Nutrition, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
J Pediatr Gastroenterol Nutr ; 74(1): 138-158, 2022 01 01.
Article em En | MEDLINE | ID: mdl-34347674
ABSTRACT: Pediatric acute liver failure (PALF) is a rare, rapidly progressive clinical syndrome with significant morbidity and mortality. The phenotype of PALF manifests as abrupt onset liver dysfunction, which can be brought via disparate etiology. Management is reliant upon intensive clinical care and support, often provided by the collaborative efforts of hepatologists, critical care specialists, and liver transplant surgeons. The construction of an age-based diagnostic approach, the identification of a potential underlying cause, and the prompt implementation of appropriate therapy can be lifesaving; however, the dynamic and rapidly progressive nature of PALF also demands that diagnostic inquiries be paired with monitoring strategies for the recognition and treatment of common complications of PALF. Although liver transplantation can provide a potential life-saving therapeutic option, the ability to confidently determine the certainness that liver transplant is needed for an individual child has been hampered by a lack of adequately tested clinical decision support tools and accurate predictive models. Given the accelerated progress in understanding PALF, we will provide clinical guidance to pediatric gastroenterologists and other pediatric providers caring for children with PALF by presenting the most recent advances in diagnosis, management, pathophysiology, and associated outcomes.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Falência Hepática Aguda / Gastroenterologia Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Prognostic_studies Limite: Child / Humans País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Gastroenterol Nutr Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Falência Hepática Aguda / Gastroenterologia Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Prognostic_studies Limite: Child / Humans País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Gastroenterol Nutr Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos