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Immunoglobulin G antibody response to the Sputnik V vaccine: previous SARS-CoV-2 seropositive individuals may need just one vaccine dose.
Claro, Franklin; Silva, Douglas; Rodriguez, Melissa; Rangel, Hector Rafael; de Waard, Jacobus H.
Afiliação
  • Claro F; Servicio Autónomo Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.
  • Silva D; Servicio Autónomo Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.
  • Rodriguez M; Servicio Autónomo Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.
  • Rangel HR; Instituto Venezolano de Investigaciones Científicas (IVIC), Los Teques, Venezuela.
  • de Waard JH; Servicio Autónomo Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela; Facultad de Ciencias de la Salud, Universidad de Las Américas (UDLA), Quito, Ecuador. Electronic address: jacobus.dewaard@udla.edu.ec.
Int J Infect Dis ; 111: 261-266, 2021 Oct.
Article em En | MEDLINE | ID: mdl-34343704
INTRODUCTION: We evaluated the immunoglobulin (Ig) G antibody response against the nucleocapsid protein (NP) and the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 in a cohort of 86 individuals in Venezuela, before and after receiving the Sputnik V vaccine. METHODS: Antibody responses against NP and RBD were determined with an enzyme-linked immunosorbent assay just before, 3 weeks after the first, and 6 weeks after the second dose of the vaccine. RESULTS: Before vaccination, 59 individuals were seronegative, and 27 seropositive for NP and/or RBD. Of the seronegative cohort, 42% did not develop an IgG immune response against RBD after the first vaccine dose, but 100% had a strong IgG response after 2 doses. All seropositive individuals developed a strong IgG antibody response against RBD after the first vaccine dose, with antibody levels ∼40% higher than seronegative individuals who had received 2 doses. Previously seropositive subjects showed no significant increase in IgG antibody response against RBD after the second vaccine dose. CONCLUSIONS: We demonstrate that 2 doses of the Sputnik V vaccine triggered antibody response in all study individuals. The second Sputnik V dose had no impact on IgG response for those seropositive for SARS-CoV-2 antigens before vaccination.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / COVID-19 Limite: Humans Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / COVID-19 Limite: Humans Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Canadá