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Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis.
Sarno, Alice; Daltro, Cleidiane Borges; Mendes, Carlos Mauricio Cardeal; Barbosa, Theolis.
Afiliação
  • Sarno A; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA, Brasil.
  • Daltro CB; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA, Brasil.
  • Mendes CMC; Universidade Federal da Bahia, Instituto de Ciências da Saúde, Salvador, BA, Brasil.
  • Barbosa T; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA, Brasil.
Rev Soc Bras Med Trop ; 54: e00172021, 2021.
Article em En | MEDLINE | ID: mdl-34320128
INTRODUCTION: Tuberculosis (TB) is the leading cause of death worldwide caused by a single infectious disease agent. Brazil, Russia, India, China, and South Africa (BRICS) account for more than half of the world's TB cases. Bacillus Calmette-Guérin (BCG) remains the only vaccine available despite its variable efficacy. Promising antigen-based vaccines have been proposed as prophylactic and/or immunotherapeutic approaches to boost BCG vaccination. Relevant antigens must interact with the range of human leukocyte antigen (HLA) molecules present in target populations; yet this information is currently not available. METHODS: MEDLINE and EMBASE were systematically searched for articles published during 2013-2020 to measure the allelic frequencies of HLA-DRB1 in the BRICS. RESULTS: In total, 67 articles involving 3,207,861 healthy individuals were included in the meta-analysis. HLA-DRB1 alleles *03, *04, *07, *11, *13, and *15 were consistently identified at high frequencies across the BRICS, with a combined estimated frequency varying from 52% to 80%. HLA-DRB1 alleles *01, *08, *09, *10, *12, and *14 were found to be relevant in only one or two BRICS populations. CONCLUSIONS: By combining these alleles, it is possible to ensure at least 80% coverage throughout the BRICS populations.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans País/Região como assunto: Africa / America do sul / Asia / Brasil / Europa Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans País/Região como assunto: Africa / America do sul / Asia / Brasil / Europa Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil