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Antibacterial Efficacy of Triple Antibiotic Medication With Macrogol (3Mix-MP), Traditional Triple Antibiotic Paste, Calcium Hydroxide, and Ethanol Extract of Propolis: An Intratubular Dentin Ex Vivo Confocal Laser Scanning Microscopic Study.
Cunha Neto, Miguel Angelo da; Coêlho, Jéssica de Almeida; Pinto, Karem Paula; Cuellar, Maricel Rosário Cardenas; Marcucci, Maria Cristina; Silva, Emmanuel João Nogueira Leal; Andrade, Flaviana Bombarda de; Sassone, Luciana Moura.
Afiliação
  • Cunha Neto MAD; PROCLIN Department, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Coêlho JA; Dentistry, Endodontics, and Dental Materials Department, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Pinto KP; PROCLIN Department, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Cuellar MRC; Dentistry, Endodontics, and Dental Materials Department, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Marcucci MC; Biosciences and Oral Diagnosis Department, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.
  • Silva EJNL; PROCLIN Department, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Andrade FB; Dentistry, Endodontics, and Dental Materials Department, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Sassone LM; PROCLIN Department, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: lucianasassone@gmail.com.
J Endod ; 47(10): 1609-1616, 2021 Oct.
Article em En | MEDLINE | ID: mdl-34310981
INTRODUCTION: This study aimed to assess the effectiveness of antibacterial activity of medications used in regenerative endodontic treatment. METHODS: Sixty-seven dentin cylinders of single-rooted teeth were contaminated with a culture of Enterococcus faecalis (ATCC 29212; American Type Culture Collection, Manassas, VA) for 5 days. Samples were divided into 1 control group and the following experimental groups according to the medication applied: traditional triple antibiotic paste (TAP), clindamycin-modified TAP (mTAP), triple antibiotic medication with macrogol (3Mix-MP), clindamycin-modified 3Mix-MP (m3Mix-MP), calcium hydroxide (CH), and ethanol extract of propolis (EEP). After 14 days, the medications were removed, and the samples were submitted to confocal laser scanning microscopic analysis to quantify the percentage of viable bacteria. The distribution of data was confirmed by the Shapiro-Wilk test. The Kruskal-Wallis and Dunn tests were used for intergroup comparisons, and the Wilcoxon test was used for comparison between superficial and deep antibacterial efficacy for the same medication. The level of significance was set at P < .05. RESULTS: 3Mix-MP and m3Mix-MP presented significantly higher antibacterial efficacy compared with the other tested medications (P < .05), except for mTAP. mTAP was more effective than TAP (P < .05). The antibacterial efficacy of EEP and CH did not differ significantly from TAP and mTAP (P > .05). All medications showed effective antibacterial action compared with the control group (P < .05). CONCLUSIONS: 3Mix-MP and m3Mix-MP, which present extremely high concentrations of antibiotics (1500 mg/mL), were not more effective than mTAP at the concentration recommended by the American Association of Endodontists (5 mg/mL). Moreover, CH and EEP were as effective as TAP and mTAP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Hidróxido de Cálcio Idioma: En Revista: J Endod Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Hidróxido de Cálcio Idioma: En Revista: J Endod Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos