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Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls.
Novaes, Natalia Pelizari; Balardin, Joana Bisol; Hirata, Fabiana Campos; Melo, Luciano; Amaro, Edson; Barbosa, Egberto Reis; Sato, João Ricardo; Cardoso, Ellison Fernando.
Afiliação
  • Novaes NP; Neurology, Universidade de São Paulo, São Paulo, Brazil.
  • Balardin JB; Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Hirata FC; Radiology, Universidade de São Paulo, São Paulo, Brazil.
  • Melo L; Hôpital du Valais, Sion, Switzerland.
  • Amaro E; Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Barbosa ER; Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Sato JR; Radiology, Universidade de São Paulo, São Paulo, Brazil.
  • Cardoso EF; Neurology, Universidade de São Paulo, São Paulo, Brazil.
Brain Behav ; 11(8): e02178, 2021 08.
Article em En | MEDLINE | ID: mdl-34302446
BACKGROUND: Graph theory (GT) is a mathematical field that analyses complex networks that can be applied to neuroimaging to quantify brain's functional systems in Parkinson's disease (PD) and essential tremor (ET). OBJECTIVES: To evaluate the functional connectivity (FC) measured by the global efficiency (GE) of the motor network in PD and compare it to ET and healthy controls (HC), and correlate it to clinical parameters. METHODS: 103 subjects (54PD, 18ET, 31HC) were submitted to structural and functional MRI. A network was designed with regions of interest (ROIs) involved in motor function, and GT was applied to determine its GE. Clinical parameters were analyzed as covariates to estimate the impact of disease severity and medication on GE. RESULTS: GE of the motor circuit was reduced in PD in comparison with HC (p .042). Areas that most contributed to it were left supplementary motor area (SMA) and bilateral postcentral gyrus. Tremor scores correlated positively with GE of the motor network in PD subgroups. For ET, there was an increase in the connectivity of the anterior cerebellar network to the other ROIs of the motor circuit in comparison with PD. CONCLUSIONS: FC measured by the GE of the motor network is diminished in PD in comparison with HC, especially due to decreased connectivity of left SMA and bilateral postcentral gyrus. This finding supports the theory that there is a global impairment of the motor network in PD, and it does not affect just the basal ganglia, but also areas associated with movement modulation. The ET group presented an increased connectivity of the anterior cerebellar network to the other ROIs of the motor circuit when compared to PD, which reinforces what it is known about its role in this pathology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Tremor Essencial Limite: Humans Idioma: En Revista: Brain Behav Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Tremor Essencial Limite: Humans Idioma: En Revista: Brain Behav Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos