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Human papillomavirus co-infection and survival in oral and oropharyngeal squamous cell carcinoma: A study in 235 Brazilian patients.
Silveira, Heitor Albergoni; Almeida, Luciana Yamamoto; Carlos, Roman; Silva, Evânio Vilela; Ferrisse, Tulio Morandin; Duarte, Andressa; Cardoso, Suziene Caroline Silva; Polanco, Xiomara Beatriz Jimenez; Bufalino, Andreia; Ribeiro-Silva, Alfredo; León, Jorge Esquiche.
Afiliação
  • Silveira HA; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP)
  • Almeida LY; Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Carlos R; Centro Clínico de Cabeza y Cuello, Guatemala City, Guatemala.
  • Silva EV; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP)
  • Ferrisse TM; Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Duarte A; Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Cardoso SCS; Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Polanco XBJ; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Bufalino A; Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Ribeiro-Silva A; Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • León JE; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address: jleon@forp.usp.br.
Auris Nasus Larynx ; 49(2): 258-270, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34274177
OBJECTIVES: While unknown for oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC), some studies assessing cervical carcinoma have shown that human papillomavirus (HPV) co-infection can be associated with its prognosis. METHODS: Through in situ hybridization (HPV and Epstein-Barr virus [EBV] probes) and immunohistochemistry (p16INK4a, cyclin D1, p53, and Ki-67 antibodies), 126 OPSCC and 109 OSCC samples were assessed. RESULTS: All patients were EBV-negative. OPSCC (25%) showed a significant association with HPV compared to OSCC (11%). Almost all HPV-associated cases were p16INK4a-positive. Regarding OPSCC and OSCC, 23 and 7 cases were positive for high-risk HPV (HRHPV) only, 6 and 3 cases for low-risk HPV (LRHPV) only, and 3 and 2 cases for HRHPV/LRHPV, respectively. HPV-associated carcinomas showed a significantly higher proliferative index than HPV-unassociated carcinomas. Both carcinomas showed a similar overall survival rate, which was not affected by the HPV status. However, when comparing HPV-associated subgroups, patients with HRHPV/LRHPV-associated carcinomas showed worse survival. CONCLUSION: LRHPV-associated and HRHPV/LRHPV-associated cases can also be detected when assessing OSCC and OPSCC. Further studies, especially in populations with a high prevalence of HPV-associated OPSCC, are necessary to understand the clinicopathological behavior of these neoplasm subgroups.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecções por Vírus Epstein-Barr / Infecções por Papillomavirus / Alphapapillomavirus / Coinfecção / Neoplasias de Cabeça e Pescoço Tipo de estudo: Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Auris Nasus Larynx Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecções por Vírus Epstein-Barr / Infecções por Papillomavirus / Alphapapillomavirus / Coinfecção / Neoplasias de Cabeça e Pescoço Tipo de estudo: Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Auris Nasus Larynx Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda