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How much epigenetics and quantitative trait loci (QTL) mapping tell us about parasitism maintenance and resistance/susceptibility to hosts.
Prado, Aline Marrara; Maia, Bárbara Maria Cerqueira; Ueta, Marlene Tiduko; Cabral, Fernanda Janku.
Afiliação
  • Prado AM; Laboratory of Integrative Entomology, Department of Animal Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
  • Maia BMC; Laboratory of Integrative Entomology, Department of Animal Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
  • Ueta MT; Laboratory of Helminthology, Department of Animal Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
  • Cabral FJ; Laboratory of Helminthology, Department of Animal Biology, University of Campinas (UNICAMP), São Paulo, Brazil. Electronic address: fjanku@unicamp.br.
Biochim Biophys Acta Mol Basis Dis ; 1867(11): 166214, 2021 11 01.
Article em En | MEDLINE | ID: mdl-34271118
Interactions between the environment, parasites, vectors, and/or intermediate hosts are complex and involve several factors that define the success or failure of an infection. Among these interactions that can affect infections by a parasite, it is possible to highlight the genetic and epigenetic mechanisms in hosts and parasites. The interaction between genetics, epigenetics, infection, and the host's internal and external environment is decisive and dictates the outcome of a parasitic infection and the resistance, susceptibility, and transmission of this parasite. Epigenetic changes become important mediators in the regulation of gene expression, allowing the evasion of the parasite to immune host barriers, its transmission to new hosts, and the end of its development cycle. Epigenetics is a new frontier in the understanding of the interaction mechanisms between parasite and host that, along with information from the gene regions associated with complex phenotypic variations, the Quantitative Trait Loci, brings new possibilities to investigate more modern and efficient approaches to the treatment, control, and eradication of parasitic diseases. In this brief review, a general overview of the use of epigenetic information and mapping of Quantitative Trait Loci was summarized, both in genes of parasites and hosts, for understanding the mechanisms of resistance and/or susceptibility in parasitic relationships; also, the main search platforms were quantitatively compared, aiming to facilitate access data produced over a period of twenty years.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Parasitárias / Locos de Características Quantitativas / Epigênese Genética / Interações Hospedeiro-Parasita Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Parasitárias / Locos de Características Quantitativas / Epigênese Genética / Interações Hospedeiro-Parasita Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda