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Unstimulated salivary flow and oral streptococci in pediatric patients with hematological tumors: A longitudinal study.
de Araújo, Elza Cristina Farias; Costa, Raphael Cavalcante; Ribeiro, Isabella Lima Arrais; Almeida, Leopoldina de Fátima Dantas de; Serpa, Eliane Batista de Medeiros; Valença, Ana Maria Gondim.
Afiliação
  • de Araújo ECF; Department of Clinical and Social Dentistry, University of Paraíba (UFPB), João Pessoa, PB, Brazil.
  • Costa RC; Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.
  • Ribeiro ILA; Department of Social Medicine, School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Almeida LFD; Department of Clinical and Social Dentistry, University of Paraíba (UFPB), João Pessoa, PB, Brazil.
  • Serpa EBM; Department of Clinical and Social Dentistry, University of Paraíba (UFPB), João Pessoa, PB, Brazil.
  • Valença AMG; Department of Clinical and Social Dentistry, University of Paraíba (UFPB), João Pessoa, PB, Brazil.
Spec Care Dentist ; 42(1): 49-59, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34240441
AIMS: To evaluate the unstimulated salivary flow (USF) and salivary colonization of total Streptococcus spp. (TS) and mutans-group (MS) in pediatric patients with hematological tumors. Correlations of salivary and microbiological changes with chemotherapy and patient-related factors were also verified. METHODS AND RESULTS: Eligible children (n = 31) were evaluated before (control) and after (2, 5, and 10-weeks) the chemotherapy protocol was applied. Saliva samples were collected by the traditional spitting method to determine the USF (ml/min). Salivary TS and MS were determined by colony-forming units (CFU ) counts in a selective medium. The caries experience was evaluated by DMFT/dmft indexes. Data were submitted to Student's t-test, one-way ANOVA, and correlation tests (α = 0.05). The USF rate at baseline was 0.89 (±0.73) ml/min with up to 20% reduction during the follow-up and did not differ statistically during chemotherapy (p  > .05). Chemotherapy did not modify the salivary TS load (p > .05), but induced a dysbiotic shift with higher MS counts (∼ 5 fold-increase) at 10-weeks (p < .05). There is a correlation of USF with age (r = .390) and SM load with caries experience (rs  = -.540) at 5-weeks. CONCLUSION: Chemotherapy may promote a specific increase of mutans-group streptococci without changing the Streptococcus spp. load and unstimulated saliva flow. Correlation reinforced the need for further enlightenment about the chemotherapy mechanisms in the salivary and microbiological parameters.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Cárie Dentária Tipo de estudo: Observational_studies Limite: Child / Humans Idioma: En Revista: Spec Care Dentist Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Cárie Dentária Tipo de estudo: Observational_studies Limite: Child / Humans Idioma: En Revista: Spec Care Dentist Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos