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Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder.
Jafarizade, Mehrian; Goli, Kiran; D'Agati, Vivette; Dulaimi, Essel; Daniel, Krupa; Lash, Bradley; Maynard, Sharon.
Afiliação
  • Jafarizade M; Department of Medicine, Division of Nephrology, Lehigh Valley Health Network, Allentown, PA.
  • Goli K; Department of Medicine, Division of Nephrology, Lehigh Valley Health Network, Allentown, PA.
  • D'Agati V; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
  • Dulaimi E; Department of Anatomic Pathology, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.
  • Daniel K; Department of Geriatrics and Extended Care, VA Medical Center, Coatesville, PA, and.
  • Lash B; Lehigh Valley Cancer Institute, Lehigh Valley Health Network, Allentown, PA, USA.
  • Maynard S; Department of Medicine, Division of Nephrology, Lehigh Valley Health Network, Allentown, PA.
Clin Nephrol Case Stud ; 9: 72-80, 2021.
Article em En | MEDLINE | ID: mdl-34235044
INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare form of B-cell lymphoma typically seen in patients with underlying immunosuppression such as HIV, autoimmune disease, and organ transplantation. PBL in HIV-positive patients usually originates from the gastrointestinal tract, with a predilection for the oral cavity. Bladder involvement by PBL is exceedingly rare, and cast nephropathy due to κ light chain-secreting PBL has not been reported previously. CASE REPORT: We report a patient who presented with acute kidney injury (AKI) in the setting of HIV, and was found to have a bladder tumor. Bladder pathology revealed a high-grade PBL with κ light chain restriction. Renal biopsy showed κ light chain cast nephropathy, presumably secondary to κ light chain-secreting PBL. CONCLUSION: Although the prognosis of PBL is poor, our patient recovered from AKI, achieved complete hematologic remission with chemotherapy, and underwent successful autologous stem cell transplant.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Clin Nephrol Case Stud Ano de publicação: 2021 Tipo de documento: Article País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Clin Nephrol Case Stud Ano de publicação: 2021 Tipo de documento: Article País de publicação: Alemanha