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The Influence of Sex and Ancestry on Three-Dimensional Palate Shape.
El Sergani, Ahmed M; Brandebura, Stephanie; Padilla, Carmencita; Butali, Azeez; Adeyemo, Wasiu L; Valencia-Ramírez, Consuelo; Muñeton, Claudia P Restrepo; Moreno, Lina M; Buxó, Carmen J; Neiswanger, Katherine; Shaffer, John R; Marazita, Mary L; Weinberg, Seth M.
Afiliação
  • El Sergani AM; Department of Oral and Craniofacial Sciences, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA.
  • Brandebura S; Department of Oral and Craniofacial Sciences, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA.
  • Padilla C; Department of Pediatrics, College of Medicine, Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila, Manila.
  • Butali A; Philippine Genome Center, University of the Philippines System, Quezon, The Philippines.
  • Adeyemo WL; Department of Oral Pathology, Radiology and Medicine, University of Iowa, Iowa City, IA.
  • Valencia-Ramírez C; Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Lagos, Nigeria.
  • Muñeton CPR; Fundación Clínica Noel, Medellin, Colombia.
  • Moreno LM; Fundación Clínica Noel, Medellin, Colombia.
  • Buxó CJ; Department of Orthodontics and The Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA.
  • Neiswanger K; Dental and Craniofacial Genomics Core, School of Dental Medicine, Medical Science Campus, University of Puerto Rico, San Juan, Puerto Rico.
  • Shaffer JR; Department of Oral and Craniofacial Sciences, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA.
  • Marazita ML; Department of Oral and Craniofacial Sciences, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA.
  • Weinberg SM; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
J Craniofac Surg ; 32(8): 2883-2887, 2021.
Article em En | MEDLINE | ID: mdl-34231514
ABSTRACT: Modern human palate shape has been reported to vary by sex and ancestry, but limitations in the methods used to quantify shape and in population coverage have led to inconsistent findings. In the present study, the authors aim to characterize the effects of sex and ancestry on normal-range three-dimensional palate shape through landmark-based morphometrics.Three-dimensional digital dental casts were obtained and landmarked from 794 adults of European (n = 429), African (n = 295), and East Asian (n = 70) ancestry. Principal component analysis was conducted to identify patterns of shape variation present in our cohort, and canonical variates analysis was performed to test for shape differences between sexes and ancestries.Principal component analysis showed that 3 principal components, explaining 76.52% of variance, linked higher palatal vault with either a relative reduction in anteroposterior or mediolateral dimensions. Canonical variates analysis showed that males had wider and shorter palates with more posteriorly located maximum vault depth than females. Individuals of African ancestry, having higher vaults with more posteriorly located maximal depths, also had wider and shorter palates, whereas individuals of European ancestry had narrower and longer palates with more anteriorly located maximum vault depths. Individuals of East Asian ancestry showed the shallowest vaults.It was found that both sex and ancestry influence palate shape, suggesting a possible genetic component underlying this variation. Additionally, our findings indicate that vault height tends to co-vary with anteroposterior or mediolateral dimensions. Further investigation of these morphological patterns may shed light on possible links to common congenital anomalies such as orofacial clefting.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palato Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Craniofac Surg Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palato Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Craniofac Surg Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos