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Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low- and Middle-Income Countries.
Jacob, Louis; Kostev, Karel; Smith, Lee; Oh, Hans; López-Sánchez, Guillermo F; Shin, Jae Il; Abduljabbar, Adel S; Haro, Josep Maria; Koyanagi, Ai.
Afiliação
  • Jacob L; Research and Development Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain.
  • Kostev K; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
  • Smith L; Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
  • Oh H; Philipps University of Marburg, Marburg, Germany.
  • López-Sánchez GF; The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK.
  • Shin JI; Suzanne Dworak Peck School of Social Work, University of Southern California, Los Angeles, CA, USA.
  • Abduljabbar AS; Vision and Eye Research Institute, School of Medicine, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University-Cambridge Campus, Cambridge, UK.
  • Haro JM; Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
  • Koyanagi A; King Saud University, Riyadh, Saudi Arabia.
J Alzheimers Dis ; 82(4): 1745-1754, 2021.
Article em En | MEDLINE | ID: mdl-34219725
BACKGROUND: Little is known about the relationship between sarcopenia and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). OBJECTIVE: This study aimed to investigate this association among community-dwelling adults aged≥65 years from six LMICs. METHODS: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. These data were obtained in China, Ghana, India, Mexico, Russia, and South Africa in 2007-2010. Participants were considered to have sarcopenia if they had low skeletal muscle mass (i.e., lower skeletal mass index) and a weak handgrip strength. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Multivariable logistic regression analysis was conducted to assess associations. RESULTS: The final analytical sample consisted of 12,912 individuals aged≥65 years with preservation in functional abilities without stroke (mean [standard deviation] age 72.2 [10.8] years; 45.2% males). The overall prevalence of sarcopenia and MCI were 11.3% and 18.1%, respectively. After adjusting for potential confounders, there was a positive association between sarcopenia and MCI in all countries (i.e., odds ratio [OR] > 1) with the exception of South Africa, and the overall estimate was OR = 1.60 (95% confidence interval [CI] = 1.32-1.93) with a low level of between-country heterogeneity (I2 = 0.0%). CONCLUSION: There was a positive association between sarcopenia and MCI in this sample of older adults living in LMICs. Causality should be assessed in future longitudinal research, while the utility of sarcopenia as a marker of MCI should also be investigated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcopenia / Vida Independente / Disfunção Cognitiva Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Aged / Female / Humans / Male País/Região como assunto: Africa / Asia / Mexico Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcopenia / Vida Independente / Disfunção Cognitiva Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Aged / Female / Humans / Male País/Região como assunto: Africa / Asia / Mexico Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha País de publicação: Holanda