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Development of a simple and rapid screening method for the detection of 1-(3-chlorophenyl)piperazine in forensic samples.
Silva, Weberson P; Rocha, Raquel G; Arantes, Luciano C; Lima, Camila D; Melo, Larissa M A; Munoz, Rodrigo A A; Dos Santos, Wallans T P; Richter, Eduardo M.
Afiliação
  • Silva WP; Institute of Chemistry, Federal University of Uberlandia, Uberlândia, Minas Gerais, 38400-092, Brazil.
  • Rocha RG; Institute of Chemistry, Federal University of Uberlandia, Uberlândia, Minas Gerais, 38400-092, Brazil.
  • Arantes LC; Seção de Perícias e Análises Laboratoriais, Instituto de Criminalística, Polícia Civil do Distrito Federal, Brasília, DF, 70610-970, Brazil.
  • Lima CD; Departament of Chemistry, Federal University of Vales Do Jequitinhonha e Mucuri, Campus JK, Diamantina, MG, 39100-000, Brazil.
  • Melo LMA; Departament of Chemistry, Federal University of Vales Do Jequitinhonha e Mucuri, Campus JK, Diamantina, MG, 39100-000, Brazil.
  • Munoz RAA; Institute of Chemistry, Federal University of Uberlandia, Uberlândia, Minas Gerais, 38400-092, Brazil.
  • Dos Santos WTP; Departament of Pharmacy, Federal University of Vales Do Jequitinhonha e Mucuri, Campus JK, Diamantina, MG, 39100-000, Brazil. Electronic address: wallanst@yahoo.com.br.
  • Richter EM; Institute of Chemistry, Federal University of Uberlandia, Uberlândia, Minas Gerais, 38400-092, Brazil. Electronic address: emrichter@ufu.br.
Talanta ; 233: 122597, 2021 Oct 01.
Article em En | MEDLINE | ID: mdl-34215085
1-(3-chlorophenyl) piperazine (mCPP) is a synthetic drug with hallucinogenic effects that has often been found in seized samples. In this context, easy to use point-of-care tests can be of great value in preliminary forensic analysis. Herein, we proposed a simple, fast, and portable electrochemical method for the detection of mCPP in seized samples. The method is based on the use of disposable screen-printed carbon electrodes (SPCE) and rapid screening procedures by square-wave voltammetry using minimal sample sizes (100 µL). mCPP showed an irreversible electrochemical oxidation process at +0.65 V on SPCE (vs Ag) using 0.04 mol L-1 Britton Robinson (BR) buffer solution (pH 7) as the supporting electrolyte. The proposed method exhibited a linear correlation (r = 0.998) between peak current and mCPP concentration in the range of 1-30 µmol L-1 (LOD = 0.1 µmol L-1). Interference studies were performed for adulterants and other classes of drugs of abuse, which can also be found in seized samples containing mCPP, such as caffeine, amphetamine, methamphetamine, 1-benzylpiperazine, 3,4-methylenedioxymethamphetamine, methylone, mephedrone, ethylone and 3, 4-methylenedioxypyrovalerone. The developed method presents great potential as a rapid and simple screening tool to detect mCPP in forensic samples.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: N-Metil-3,4-Metilenodioxianfetamina Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Talanta Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: N-Metil-3,4-Metilenodioxianfetamina Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Talanta Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda