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Genome Mining for Antimicrobial Compounds in Wild Marine Animals-Associated Enterococci.
Prichula, Janira; Primon-Barros, Muriel; Luz, Romeu C Z; Castro, Ícaro M S; Paim, Thiago G S; Tavares, Maurício; Ligabue-Braun, Rodrigo; d'Azevedo, Pedro A; Frazzon, Jeverson; Frazzon, Ana P G; Seixas, Adriana; Gilmore, Michael S.
Afiliação
  • Prichula J; Gram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
  • Primon-Barros M; Gram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
  • Luz RCZ; Gram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
  • Castro ÍMS; Gram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
  • Paim TGS; Gram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
  • Tavares M; Centro de Estudos Costeiros, Limnológicos e Marinhos (CECLIMAR), Universidade Federal do Rio Grande do Sul (UFRGS), Campus Litoral Norte, Imbé 95625-000, RS, Brazil.
  • Ligabue-Braun R; Department of Pharmacosciences, UFCSPA, Porto Alegre 90050-170, RS, Brazil.
  • d'Azevedo PA; Gram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
  • Frazzon J; Food Science Institute, UFRGS, Porto Alegre 90035-003, RS, Brazil.
  • Frazzon APG; Department of Microbiology, Immunology and Parasitology, UFRGS, Porto Alegre 90050-170, RS, Brazil.
  • Seixas A; Department of Pharmacosciences, UFCSPA, Porto Alegre 90050-170, RS, Brazil.
  • Gilmore MS; Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Mar Drugs ; 19(6)2021 Jun 06.
Article em En | MEDLINE | ID: mdl-34204046
New ecosystems are being actively mined for new bioactive compounds. Because of the large amount of unexplored biodiversity, bacteria from marine environments are especially promising. Further, host-associated microbes are of special interest because of their low toxicity and compatibility with host health. Here, we identified and characterized biosynthetic gene clusters encoding antimicrobial compounds in host-associated enterococci recovered from fecal samples of wild marine animals remote from human-affected ecosystems. Putative biosynthetic gene clusters in the genomes of 22 Enterococcus strains of marine origin were predicted using antiSMASH5 and Bagel4 bioinformatic software. At least one gene cluster encoding a putative bioactive compound precursor was identified in each genome. Collectively, 73 putative antimicrobial compounds were identified, including 61 bacteriocins (83.56%), 10 terpenes (13.70%), and 2 (2.74%) related to putative nonribosomal peptides (NRPs). Two of the species studied, Enterococcus avium and Enterococcus mundtti, are rare causes of human disease and were found to lack any known pathogenic determinants but yet possessed bacteriocin biosynthetic genes, suggesting possible additional utility as probiotics. Wild marine animal-associated enterococci from human-remote ecosystems provide a potentially rich source for new antimicrobial compounds of therapeutic and industrial value and potential probiotic application.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terpenos / Bacteriocinas / Enterococcus / Probióticos / Organismos Aquáticos / Animais Selvagens / Anti-Infecciosos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terpenos / Bacteriocinas / Enterococcus / Probióticos / Organismos Aquáticos / Animais Selvagens / Anti-Infecciosos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça