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Short-Term Strength Exercise Reduces Hepatic Insulin Resistance in Obese Mice by Reducing PTP1B Content, Regardless of Changes in Body Weight.
da Cruz Rodrigues, Kellen Cristina; Martins Pereira, Rodrigo; Peruca, Guilherme Francisco; Torres Barbosa, Lucas Wesley; Ramos Sant'Ana, Marcella; Rosetto Muñoz, Vitor; Morelli, Ana Paula; Moreira Simabuco, Fernando; Sanchez Ramos da Silva, Adelino; Esper Cintra, Dennys; Rochete Ropelle, Eduardo; Pauli, José Rodrigo; de Moura, Leandro Pereira.
Afiliação
  • da Cruz Rodrigues KC; Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • Martins Pereira R; Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • Peruca GF; Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • Torres Barbosa LW; Laboratory of Molecular Biology of Exercise, Faculty of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • Ramos Sant'Ana M; Laboratory of Nutritional Genomics, School of Applied Sciences, State University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • Rosetto Muñoz V; Laboratory of Molecular Biology of Exercise, Faculty of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • Morelli AP; Multidisciplinary Laboratory of Food and Health, Faculty of Applied Sciences (FCA), State University of Campinas (UNICAMP), Limeira 13484-350, SP, Brazil.
  • Moreira Simabuco F; Multidisciplinary Laboratory of Food and Health, Faculty of Applied Sciences (FCA), State University of Campinas (UNICAMP), Limeira 13484-350, SP, Brazil.
  • Sanchez Ramos da Silva A; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, 3900 Bandeirantes Avenue, Ribeirão Preto 14040-907, SP, Brazil.
  • Esper Cintra D; Laboratory of Nutritional Genomics, School of Applied Sciences, State University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • Rochete Ropelle E; Laboratory of Molecular Biology of Exercise, Faculty of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • Pauli JR; Laboratory of Molecular Biology of Exercise, Faculty of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
  • de Moura LP; Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, 1300 Pedro Zaccaria Street, Limeira 13484-350, SP, Brazil.
Int J Mol Sci ; 22(12)2021 Jun 15.
Article em En | MEDLINE | ID: mdl-34203825
Obesity is closely related to insulin resistance and type 2 diabetes genesis. The liver is a key organ to glucose homeostasis since insulin resistance in this organ increases hepatic glucose production (HGP) and fasting hyperglycemia. The protein-tyrosine phosphatase 1B (PTP1B) may dephosphorylate the IR and IRS, contributing to insulin resistance in this organ. Aerobic exercise is a great strategy to increase insulin action in the liver by reducing the PTP1B content. In contrast, no study has shown the direct effects of strength training on the hepatic metabolism of PTP1B. Therefore, this study aims to investigate the effects of short-term strength exercise (STSE) on hepatic insulin sensitivity and PTP1B content in obese mice, regardless of body weight change. To achieve this goal, obese Swiss mice were submitted to a strength exercise protocol lasting 15 days. The results showed that STSE increased Akt phosphorylation in the liver and enhanced the control of HGP during the pyruvate tolerance test. Furthermore, sedentary obese animals increased PTP1B content and decreased IRS-1/2 tyrosine phosphorylation; however, STSE was able to reverse this scenario. Therefore, we conclude that STSE is an important strategy to improve the hepatic insulin sensitivity and HGP by reducing the PTP1B content in the liver of obese mice, regardless of changes in body weight.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Peso Corporal / Resistência à Insulina / Proteína Tirosina Fosfatase não Receptora Tipo 1 Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Peso Corporal / Resistência à Insulina / Proteína Tirosina Fosfatase não Receptora Tipo 1 Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça