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Bacterial Photoinactivation Using PLGA Electrospun Scaffolds.
Pereira, Aline O; Lopes, Isabella M I; Silva, Thiago R; Corrêa, Thaila Q; Paschoalin, Rafaella T; Inada, Natalia M; Iermak, Ievgeniia; van Riel Neto, Francisco; Araujo-Chaves, Juliana C; Marletta, Alexandre; Tozoni, José R; Mattoso, Luiz Henrique C; Bagnato, Vanderlei S; Nantes-Cardoso, Iseli L; Oliveira, Osvaldo N; Campana, Patricia T.
Afiliação
  • Pereira AO; School of Arts, Sciences and Humanities, University of São Paulo (USP), Arlindo Bettio Av., 1000, São Paulo 03828-000, Brazil.
  • Lopes IMI; School of Arts, Sciences and Humanities, University of São Paulo (USP), Arlindo Bettio Av., 1000, São Paulo 03828-000, Brazil.
  • Silva TR; School of Arts, Sciences and Humanities, University of São Paulo (USP), Arlindo Bettio Av., 1000, São Paulo 03828-000, Brazil.
  • Corrêa TQ; Sao Carlos Institute of Physics, University of São Paulo (USP), Trabalhador São-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
  • Paschoalin RT; Sao Carlos Institute of Physics, University of São Paulo (USP), Trabalhador São-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
  • Inada NM; Nanotechnology National Laboratory for Agriculture (LNNA), Embrapa Instrumentation, 15 de Novembro St., 1452, São Carlos 13560-970, Brazil.
  • Iermak I; Sao Carlos Institute of Physics, University of São Paulo (USP), Trabalhador São-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
  • van Riel Neto F; Sao Carlos Institute of Physics, University of São Paulo (USP), Trabalhador São-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
  • Araujo-Chaves JC; Institute of Physics, Federal University of Uberlândia (UFU), João Naves de Ávila Av., 2121, Uberlândia 38408-100, Brazil.
  • Marletta A; Center of Natural Sciences and HumanitiesFederal University of ABC (UFABC), dos Estados Av., 5001, Santo André 09210-580, Brazil.
  • Tozoni JR; Institute of Physics, Federal University of Uberlândia (UFU), João Naves de Ávila Av., 2121, Uberlândia 38408-100, Brazil.
  • Mattoso LHC; Institute of Physics, Federal University of Uberlândia (UFU), João Naves de Ávila Av., 2121, Uberlândia 38408-100, Brazil.
  • Bagnato VS; Nanotechnology National Laboratory for Agriculture (LNNA), Embrapa Instrumentation, 15 de Novembro St., 1452, São Carlos 13560-970, Brazil.
  • Nantes-Cardoso IL; Sao Carlos Institute of Physics, University of São Paulo (USP), Trabalhador São-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
  • Oliveira ON; Center of Natural Sciences and HumanitiesFederal University of ABC (UFABC), dos Estados Av., 5001, Santo André 09210-580, Brazil.
  • Campana PT; Sao Carlos Institute of Physics, University of São Paulo (USP), Trabalhador São-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
ACS Appl Mater Interfaces ; 13(27): 31406-31417, 2021 Jul 14.
Article em En | MEDLINE | ID: mdl-34185501
The use of ultraviolet (UV) and blue irradiation to sterilize surfaces is well established, but commercial applications would be enhanced if the light source is replaced with ambient light. In this paper, it is shown that nanofibers can be explored as an alternative methodology to UV and blue irradiation for bacterial inactivation. It is demonstrated that this is indeed possible using spun nanofibers of poly[lactic-co-(glycolic acid)] (PLGA). This work shows that PLGA spun scaffolds can promote photoinactivation of Staphylococcus aureus and Escherichia coli bacteria with ambient light or with laser irradiation at 630 nm. With the optimized scaffold composition of PLGA85:15 nanofibers, the minimum intensity required to kill the bacteria is much lower than in antimicrobial blue light applications. The enhanced effect introduced by PLGA scaffolds is due to their nanofiber structures since PLGA spun nanofibers were able to inactivate both S. aureus and E. coli bacteria, but cast films had no effect. These findings pave the way for an entirely different method to sterilize surfaces, which is less costly and environmentally friendly than current procedures. In addition, the scaffolds could also be used in cancer treatment with fewer side effects since photosensitizers are not required.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Raios Ultravioleta / Eletricidade / Escherichia coli / Viabilidade Microbiana / Copolímero de Ácido Poliláctico e Ácido Poliglicólico Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Raios Ultravioleta / Eletricidade / Escherichia coli / Viabilidade Microbiana / Copolímero de Ácido Poliláctico e Ácido Poliglicólico Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos