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Acute Liver Injury Among Pediatric Liver Transplantation Recipients With Coronavirus Disease 2019: An International Collaborative Study.
Sin, Priscila; Díaz, Luis Antonio; Martínez, Mercedes; Vizcaya, Cecilia; D'Agostino, Daniel; Gana, Juan Cristóbal.
Afiliação
  • Sin P; Department of Gastroenterology and Nutrition, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Díaz LA; Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Martínez M; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Abdominal Organ transplant, New York Presbyterian Hospital, Columbia University, New York, USA.
  • Vizcaya C; Department of Infectology, Immunology and Pediatric Reumatology, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • D'Agostino D; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, Liver and Intestinal Transplantation, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
  • Gana JC; Department of Gastroenterology and Nutrition, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
J Pediatr Gastroenterol Nutr ; 73(3): 391-394, 2021 09 01.
Article em En | MEDLINE | ID: mdl-34183614
ABSTRACT: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic. The occurrence of acute liver injury (ALI) has been reported in liver transplant (LT) recipients; however, the findings on children remain controversial. This is the first extensive, worldwide report on the impact of COVID-19 on pediatric LT recipients. Our online survey reported 110 pediatric LT recipients with severe acute respiratory syndrome coronavirus 2 infection. Of these, 37 were symptomatic and 20 out of them (54%) had complicated COVID-19, which included ALI and acute liver graft rejection. No mortality was reported. Pediatric LT recipients who had undergone transplantation less than 6 months before contracting COVID-19 had a greater number of hospital admissions and a higher ALI frequency (P = 0.013 and P = 0.033, respectively) than those who had undergone transplantation more than 6 months prior. Our study found that COVID-19 cases among pediatric LT recipients demonstrated a high complication rate. We propose that these patients must be followed up strictly.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / COVID-19 Limite: Child / Humans Idioma: En Revista: J Pediatr Gastroenterol Nutr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / COVID-19 Limite: Child / Humans Idioma: En Revista: J Pediatr Gastroenterol Nutr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos