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Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation.
de Almeida-Filho, Daniel Gomes; Koike, Bruna Del Vechio; Billwiller, Francesca; Farias, Kelly Soares; de Sales, Igor Rafael Praxedes; Luppi, Pierre-Hervé; Ribeiro, Sidarta; Queiroz, Claudio Marcos.
Afiliação
  • de Almeida-Filho DG; Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Koike BDV; Department of Neurobiology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, CA, 90095, USA.
  • Billwiller F; Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Farias KS; UMR 5292 CNRS/U1028 INSERM, Center of Research in Neuroscience of Lyon, SLEEP Team, Université Claude Bernard Lyon I, Faculté de Médecine RTH Laennec, Lyon, France.
  • de Sales IRP; Federal University of the São Francisco Valley, Petrolina, PE, Brazil.
  • Luppi PH; UMR 5292 CNRS/U1028 INSERM, Center of Research in Neuroscience of Lyon, SLEEP Team, Université Claude Bernard Lyon I, Faculté de Médecine RTH Laennec, Lyon, France.
  • Ribeiro S; Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Queiroz CM; UMR 5292 CNRS/U1028 INSERM, Center of Research in Neuroscience of Lyon, SLEEP Team, Université Claude Bernard Lyon I, Faculté de Médecine RTH Laennec, Lyon, France.
Sci Rep ; 11(1): 13078, 2021 06 22.
Article em En | MEDLINE | ID: mdl-34158548
Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono REM / Consolidação da Memória / Giro do Cíngulo Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono REM / Consolidação da Memória / Giro do Cíngulo Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido