Your browser doesn't support javascript.
loading
Outcomes of Patients With Metastatic Anal Cancer According to HIV Infection: A Multicenter Study by the Latin American Gastrointestinal Oncology Group (SLAGO).
Mattos, Bruna R S; Camandaroba, Marcos P G; Ruiz-Garcia, Erika; Diaz-Romero, Consuelo; Luca, Romina; Mendez, Guillermo; Lustosa, Iara K F; Silva, Sinara F; Mello, Celso A; Silva, Virgilio S; O'Connor, Juan M; Riechelmann, Rachel P.
Afiliação
  • Mattos BRS; A.C. Camargo Cancer Center, Fundação Antonio Prudente, Sao Paulo, Brazil.
  • Camandaroba MPG; A.C. Camargo Cancer Center, Fundação Antonio Prudente, Sao Paulo, Brazil.
  • Ruiz-Garcia E; The National Cancer Institute, Mexico City, Mexico.
  • Diaz-Romero C; The National Cancer Institute, Mexico City, Mexico.
  • Luca R; Institute Alexander Fleming, Buenos Aires, Argentina.
  • Mendez G; Favaloro Foundation University Hospital, Buenos Aires, Argentina.
  • Lustosa IKF; A.C. Camargo Cancer Center, Fundação Antonio Prudente, Sao Paulo, Brazil.
  • Silva SF; A.C. Camargo Cancer Center, Fundação Antonio Prudente, Sao Paulo, Brazil.
  • Mello CA; A.C. Camargo Cancer Center, Fundação Antonio Prudente, Sao Paulo, Brazil.
  • Silva VS; A.C. Camargo Cancer Center, Fundação Antonio Prudente, Sao Paulo, Brazil.
  • O'Connor JM; Institute Alexander Fleming, Buenos Aires, Argentina.
  • Riechelmann RP; A.C. Camargo Cancer Center, Fundação Antonio Prudente, Sao Paulo, Brazil. Electronic address: rachel.riechelmann@accamargo.org.br.
Clin Colorectal Cancer ; 20(4): 299-304, 2021 12.
Article em En | MEDLINE | ID: mdl-34158252
BACKGROUND: HIV-positive patients are underrepresented in clinical trials of metastatic squamous cell carcinoma of the anal canal (mSCCA). We aimed to compare the clinical outcomes of mSCCA patients according to HIV infection. METHODS: This was a retrospective multicenter cohort study of consecutive patients with mSCCA. All HIV-positive patients received antiretroviral therapy. The primary endpoint was overall survival (OS), and secondary endpoints were progression-free survival (PFS) and response rate (RR). RESULTS: From January 2005 to December 2019, 113 patients were included: 20 (17.6%) had HIV infection. HIV-positive patients were younger at diagnosis and more frequently male, and 20% (n = 8) received exclusively best supportive care in comparison with 8.6% of HIV-negative patients (P = .13). Both groups were similar in terms of Eastern Cooperative Oncology Group (ECOG) performance status, pattern of metastatic disease, and type of first-line chemotherapy. Five (25%) HIV-positive and 36 (38.7%) HIV-negative patients received second-line therapies (P = .24). RR and median PFS in first-line were similar between the groups: 35% and 30.1% (P = .78) and 4.9 and 5.3 months (P = .85) for patients with and without HIV infection, respectively. At a median follow-up of 26 months, median OS was 11.3 months (95% confidence interval [CI] 10.1 to 26.4) for HIV-infected patients versus 14.6 months (95% CI 11.1 to 18.1) for HIV-negative patients (P = .92). In the univariate analysis for OS, only ECOG performance status was significant. CONCLUSION: HIV-positive mSCCA patients under antiretroviral therapy have oncological outcomes similar to those of HIV-negative patients. These patients should be included in trials of mSCCA.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Ânus / Infecções por HIV Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Clin Colorectal Cancer Assunto da revista: GASTROENTEROLOGIA / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Ânus / Infecções por HIV Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Clin Colorectal Cancer Assunto da revista: GASTROENTEROLOGIA / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos