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Long-Term Neurodevelopmental Outcomes of Children with Congenital Heart Defects.
Derridj, Neil; Guedj, Romain; Calderon, Johanna; Houyel, Lucile; Lelong, Nathalie; Bertille, Nathalie; Goffinet, Francois; Bonnet, Damien; Khoshnood, Babak.
Afiliação
  • Derridj N; M3C-Pediatric Cardiology, Necker Enfants malades, AP-HP, Université de Paris, Paris, France; Université de Paris, CRESS, INSERM, INRA, F-75004, Paris, France. Electronic address: neil.derridj@inserm.fr.
  • Guedj R; Université de Paris, CRESS, INSERM, INRA, F-75004, Paris, France; Pediatric Emergency Department, AP-HP, Armand Trousseau Hospital, Sorbonne Université, Paris, France.
  • Calderon J; Department of Psychiatry, Harvard Medical School, Boston, MA; Department of Psychiatry, Cardiac Neurodevelopmental Program, Boston Children's Hospital, Boston, MA.
  • Houyel L; M3C-Pediatric Cardiology, Necker Enfants malades, AP-HP, Université de Paris, Paris, France.
  • Lelong N; Université de Paris, CRESS, INSERM, INRA, F-75004, Paris, France.
  • Bertille N; Université de Paris, CRESS, INSERM, INRA, F-75004, Paris, France.
  • Goffinet F; Université de Paris, CRESS, INSERM, INRA, F-75004, Paris, France.
  • Bonnet D; M3C-Pediatric Cardiology, Necker Enfants malades, AP-HP, Université de Paris, Paris, France.
  • Khoshnood B; Université de Paris, CRESS, INSERM, INRA, F-75004, Paris, France.
J Pediatr ; 237: 109-114.e5, 2021 Oct.
Article em En | MEDLINE | ID: mdl-34157347
OBJECTIVE: To assess whether children with symptomatic congenital heart defects (CHDs) at birth (cyanosis and/or heart failure) are at greater risk of adverse neurodevelopmental outcomes at 8 years of age. STUDY DESIGN: From a prospective population-based cohort study of newborns with CHDs (EPICARD), we included 473 children with available neurodevelopmental assessments at 8 years of age. We grouped the CHD based on symptoms at birth and need for early neonatal intervention. Ventricular septal defects that closed spontaneously within the first year of life were considered the control group. Neurodevelopmental outcomes were assessed using the Kauffman Assessment Battery Test for Children, Second Edition, for IQ (mean 100 ± 15), and the Developmental NEuroPSYchological Assessment Battery, Second Edition, for detailed assessment of specific neurocognitive domains (mean 10 ± 3). Multivariable regression analysis was used to compare the outcomes across the CHD groups after considering potentially confounding variables. RESULTS: Compared with the control group, children with cyanotic CHD without heart failure had lower scores for IQ, -7.2 (95% CI -13.4 to -1.2). Children with noncyanotic CHD with heart failure had lower scores in the specific domains of language -1.5 (95% CI -2.2 to -0.7), and memory and learning -1.3 (95% CI -2.4; -0.3). Those with both cyanotic CHD and heart failure had lower scores for IQ, -7.6 (95% CI -13.5 to -1.8), as well as the specific domains of language and memory and learning, -2.0 (95% CI -2.9 to -1.0) and -1.1 (95% CI -2.3 to -0.1), respectively. CONCLUSIONS: Children with symptomatic CHD at birth are at greater risk of adverse neurodevelopmental outcomes at 8 years of age, with the greatest risk for those who were born with both cyanosis and heart failure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Neurodesenvolvimento / Cardiopatias Congênitas Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Neurodesenvolvimento / Cardiopatias Congênitas Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos