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Anosognosia in dementia with Lewy bodies: a systematic review.
Calil, Victor; Sudo, Felipe Kenji; Santiago-Bravo, Gustavo; Lima, Marco Antonio; Mattos, Paulo.
Afiliação
  • Calil V; Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro RJ, Brazil.
  • Sudo FK; Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa de Pós-Graduação em Clínica Médica, Rio de Janeiro RJ, Brazil.
  • Santiago-Bravo G; Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro RJ, Brazil.
  • Lima MA; Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro RJ, Brazil.
  • Mattos P; Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa de Pós-Graduação em Clínica Médica, Rio de Janeiro RJ, Brazil.
Arq Neuropsiquiatr ; 79(4): 334-342, 2021 04.
Article em En | MEDLINE | ID: mdl-34133514
BACKGROUND: Anosognosia, i.e. lack of awareness of one's own symptoms, is a very common finding in patients with dementia and is related to neuropsychiatric symptoms and worse prognosis. Although dementia with Lewy bodies (DLB) is the second most common form of degenerative dementia, literature on anosognosia in this disease is scarce. OBJECTIVES: This paper aimed to review the current evidence on anosognosia in patients with DLB, including its prevalence in comparison with other neurological conditions, its severity and anatomical correlations. METHODS: Database searches were performed in PubMed, Web of Knowledge and PsycINFO for articles assessing anosognosia in DLB. A total of 243 studies were retrieved, but only six were included in the review. RESULTS: Potential risk of selection, comparison or outcome biases were detected in relation to all the studies selected. Most of the studies used self-report memory questionnaires to assess cognitive complaints and compared their results to scores from informant-based instruments or to participants' cognitive performance in neuropsychological tasks. Subjects with DLB had worse awareness regarding memory than healthy older controls, but the results concerning differences in anosognosia between DLB and Alzheimer's disease (AD) patients were inconsistent across studies. Presence of AD pathology and neuroimaging biomarkers appeared to increase the prevalence of anosognosia in individuals with DLB. CONCLUSION: Anosognosia is a common manifestation of DLB, but it is not clear how its prevalence and severity compare with AD. Co-existence of AD pathology seems to play a role in memory deficit awareness in DLB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Agnosia / Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Arq Neuropsiquiatr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Agnosia / Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Arq Neuropsiquiatr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha