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Validation of Spanish version of 15-item myasthenia gravis quality-of-life questionnaire.
Contreras, Juan Pablo; Salinas, Rodrigo; Vidal, Carolina; Hoffmeister, Lorena; Wolfe, Gil I; Cea, Gabriel.
Afiliação
  • Contreras JP; Departamento de Ciencias Neurologicas Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
  • Salinas R; Departamento de Ciencias Neurologicas Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
  • Vidal C; Servicio de Neurologia, Hospital Salvador, Servicio de Salud Metropolitano Oriente, Santiago, Chile.
  • Hoffmeister L; Escuela de Salud Pública, Universidad Mayor, Santiago, Chile.
  • Wolfe GI; Escuela de Salud Pública, Universidad Mayor, Santiago, Chile.
  • Cea G; Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY, USA.
Acta Neurol Scand ; 144(5): 546-552, 2021 Nov.
Article em En | MEDLINE | ID: mdl-34131909
OBJECTIVES: The aim of this study was to achieve the translation and cross-cultural adaptation of the MG-QOL15R questionnaire into Spanish and the analysis of its psychometric properties. MATERIALS AND METHODS: We recruited patients with MG, ≥18 years old, whose mother tongue was Spanish. After the translation and cross-cultural adaptation of the MG-QOL15-R, the following tests were performed: internal consistency using the Cronbach-α coefficient and corrected item-total correlations; reproducibility with a test-retest analysis using intraclass correlation coefficients; and concurrent validity using Spearman's correlation coefficient of the Spanish language MG-QOL15R-S, Myasthenia Gravis Activity of Daily Living (MG-ADL) and Quantitative Myasthenia Gravis (QMG) scores. As an approximation to construct validity, the nonparametric Mann-Whitney U test was performed between MG-QOL15R-S scores according to the Myasthenia Gravis Foundation of America classification. RESULTS: A total of 83 MG patients were enrolled, mean age 48.19 ± 17.25 years; 58 (69.9%) were women. The mean MG-QOL15R-S score was 11.3 ± 7.1. Cronbach-α coefficient was 0.92. Item-total correlation ranged between 0.43 and 0.75. Intraclass correlation coefficient was 0.80. The Spearman correlation coefficient was 0.637 (p-value < .001) for MG-ADL and 0.487 (p-value < .001) for QMG. Mann-Whitney U tests of the mean MG-QOL15R-S scores were significantly different according to the clinical severity (p-value < .001). CONCLUSIONS: The Spanish version of the MG-QOL15R is a valid and reliable instrument and potentially useful for measuring health-related quality of life in Spanish-speaking MG patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Miastenia Gravis Tipo de estudo: Diagnostic_studies Aspecto: Patient_preference Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Acta Neurol Scand Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Chile País de publicação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Miastenia Gravis Tipo de estudo: Diagnostic_studies Aspecto: Patient_preference Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Acta Neurol Scand Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Chile País de publicação: Dinamarca