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Mapping the Cerebellar Cognitive Affective Syndrome in Patients with Chronic Cerebellar Strokes.
Chirino-Pérez, Amanda; Marrufo-Meléndez, Oscar René; Muñoz-López, José Ignacio; Hernandez-Castillo, Carlos R; Ramirez-Garcia, Gabriel; Díaz, Rosalinda; Nuñez-Orozco, Lilia; Fernandez-Ruiz, Juan.
Afiliação
  • Chirino-Pérez A; Neuropsychology Laboratory, Physiology Department, School of Medicine, National Autonomous University of Mexico, 04510, Mexico city, Mexico.
  • Marrufo-Meléndez OR; Neuroimaging Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", 14269, Mexico city, Mexico.
  • Muñoz-López JI; Neuroimaging Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", 14269, Mexico city, Mexico.
  • Hernandez-Castillo CR; CONACYT - Institute of Neuroethology, Universidad Veracruzana, 91190, Xalapa, Veracruz, Mexico.
  • Ramirez-Garcia G; Neuropsychology Laboratory, Physiology Department, School of Medicine, National Autonomous University of Mexico, 04510, Mexico city, Mexico.
  • Díaz R; Neuropsychology Laboratory, Physiology Department, School of Medicine, National Autonomous University of Mexico, 04510, Mexico city, Mexico.
  • Nuñez-Orozco L; Neurology Service, National Medical Center 20 de Noviembre, Institute of Social Security and Services for State Workers, 03229, Mexico city, Mexico.
  • Fernandez-Ruiz J; Neuropsychology Laboratory, Physiology Department, School of Medicine, National Autonomous University of Mexico, 04510, Mexico city, Mexico. jfr@unam.mx.
Cerebellum ; 21(2): 208-218, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34109552
The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the "language" functional boundaries in the cerebellum. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cerebelares / Transtornos Cognitivos / Acidente Vascular Cerebral Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Cerebellum Assunto da revista: CEREBRO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cerebelares / Transtornos Cognitivos / Acidente Vascular Cerebral Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Cerebellum Assunto da revista: CEREBRO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos