Ovine prolactin and human growth hormone derivatives. Specific modification of their alpha-amino groups.
Int J Pept Protein Res
; 31(6): 509-13, 1988 Jun.
Article
em En
| MEDLINE
| ID: mdl-3410636
The alpha-amino group of ovine prolactin (oPRL) and human growth hormone (hGH) was selectively modified by transamination with glyoxylic acid. No difference was found in the binding capacity of transaminated oPRL to rat liver lactogenic receptors with respect to its control, although both samples showed a decrease in its binding capacity with reference to the native hormone. This decrease was due to conformational changes caused by the reaction conditions and not by the transamination itself, as shown by the circular dichroism spectra. Transaminated hGH retained the full binding capacity of the hormone. These results suggest that the alpha-amino group is not relevant for the binding to lactogenic liver receptors in both lactogenic hormones.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prolactina
/
Hormônio do Crescimento
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Pept Protein Res
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Dinamarca