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Association of genetic polymorphisms NCF4 rs1883112, CBR3 rs1056892, and ABCC1 rs3743527 with the cardiotoxic effects of doxorubicin in children with acute lymphoblastic leukemia.
Gándara-Mireles, Jesús Alonso; Lares-Asseff, Ismael; Reyes Espinoza, Elio Aarón; Blanco, Javier G; González Font, Antonio Emilio; Córdova Hurtado, Lourdes Patricia; Castañeda, Verónica Loera; Fierro, Ignacio Villanueva; Romero, Leslie Patrón; Reyes, Horacio Almanza.
Afiliação
  • Gándara-Mireles JA; Academia de Genómica, Instituto Politécnico Nacional, CIIDIR-Unidad, Durango, Mexico.
  • Lares-Asseff I; Academia de Genómica, Instituto Politécnico Nacional, CIIDIR-Unidad, Durango, Mexico.
  • Reyes Espinoza EA; Red Latinoamericana de Implementación y Validación de Guías Clínicas Farmacogenómicas (RELIVAF-CYTED).
  • Blanco JG; Servicio de Hemato-Oncologia Pediatrica, Centro Estatal de Cancerología, CECAN, Durango, Mexico.
  • González Font AE; School of Pharmacy and Pharmaceutical Sciences, University of Buffalo, The State University of New York, USA.
  • Córdova Hurtado LP; Service de Cardiología Pediatricá, Hospital Materno Infantil, Servicios de Salud de Durango.
  • Castañeda VL; Servicio de Hemato-Oncologia Pediatrica, Centro Estatal de Cancerología, CECAN, Durango, Mexico.
  • Fierro IV; Academia de Genómica, Instituto Politécnico Nacional, CIIDIR-Unidad, Durango, Mexico.
  • Romero LP; Academia de Genómica, Instituto Politécnico Nacional, CIIDIR-Unidad, Durango, Mexico.
  • Reyes HA; Facultad de Medicina y Psicologia de la Universidad Autónoma de Baja California, Tijuana, Mexico.
Pharmacogenet Genomics ; 31(5): 108-115, 2021 07 01.
Article em En | MEDLINE | ID: mdl-34096893
OBJECTIVES: Cardiotoxicity is a frequent complication secondary to the use of anthracyclines for cancer chemotherapy. Evidence suggests that certain polymorphic genetic variants modify the risk for anthracycline-related cardiotoxicity. Reports documenting the impact of genetic polymorphisms on anthracycline-cardiotoxicity risk in pediatric patients with cancers from Latin American countries are scarce. The objective of this study was to evaluate associations between NCF4 rs1883112, CBR3 rs1056892 and ABCC1 rs3743527 genotype status and echocardiographic parameters indicative of anthracycline-cardiotoxicity in a group of Mexican children with acute lymphoblastic leukemia (ALL). METHODS: Sixty-seven children (2-18 years old) with ALL were treated at the State Cancer Center in Durango, Mexico. NCF4, CBR3, and ABCC1 genotypes were examined by real-time PCR. Left ventricular ejection fraction and diastolic filling ratio were examined as markers of systolic and diastolic anthracycline-toxicity. RESULTS: NCF4 rs1883112 genotype status was significantly associated with the risk of doxorubicin cardiotoxicity [odds ratio (OR) = 10.80, 95% confidence interval (CI) 1.69-68.98, P = 0.01]. There was a significant association between heterozygous CBR3 rs1056892 genotype status and anthracycline-cardiotoxicity risk (OR = 9.91, 95% CI 1.07-91.47, P = 0.04). Heterozygosis for the ABCC1 rs3743527 allele was associated with protection from anthracycline-cardiotoxicity (OR = 0.30, 95% CI 0.09-0.91, P = 0.03). CONCLUSION: This pilot study suggests that selected polymorphic variants may impact the risk for anthracycline-cardiotoxicity in pediatric patients with ALL treated with a contemporary chemotherapeutic regimen in Mexico.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Cardiotoxicidade Tipo de estudo: Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Humans Idioma: En Revista: Pharmacogenet Genomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Cardiotoxicidade Tipo de estudo: Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Humans Idioma: En Revista: Pharmacogenet Genomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos