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Sandpaper-based electrochemical devices assembled on a reusable 3D-printed holder to detect date rape drug in beverages.
Rocha, Danielly S; Duarte, Lucas C; Silva-Neto, Habdias A; Chagas, Cyro L S; Santana, Mário H P; Antoniosi Filho, Nelson R; Coltro, Wendell K T.
Afiliação
  • Rocha DS; Instituto de Química, Universidade Federal de Goiás, 74690-900, Goiânia, GO, Brazil.
  • Duarte LC; Instituto de Química, Universidade Federal de Goiás, 74690-900, Goiânia, GO, Brazil.
  • Silva-Neto HA; Instituto de Química, Universidade Federal de Goiás, 74690-900, Goiânia, GO, Brazil.
  • Chagas CLS; Instituto de Química, Universidade de Brasília, 70910-900, Brasília, DF, Brazil.
  • Santana MHP; Unidade Técnico-Científica - Superintendência Regional da Polícia Federal Em MG, Uberlândia, MG, 38408- 6630, Brazil.
  • Antoniosi Filho NR; Instituto de Química, Universidade Federal de Goiás, 74690-900, Goiânia, GO, Brazil.
  • Coltro WKT; Instituto de Química, Universidade Federal de Goiás, 74690-900, Goiânia, GO, Brazil; Instituto Nacional de Ciência e Tecnologia de Bioanalítica, 13083-861, Campinas, SP, Brazil. Electronic address: wendell@ufg.br.
Talanta ; 232: 122408, 2021 Sep 01.
Article em En | MEDLINE | ID: mdl-34074398
This study describes the development of a new electrochemical paper-based analytical device (ePAD) on alumina sandpaper substrate through a pencil-drawing process for square wave voltammetry measurements of midazolam maleate used as a "date rape drug" in beverages. The proposed ePAD was assembled on a reusable 3D printed holder to delimit its geometric area and ensure better robustness. The ePAD was characterized by scanning electron microscopy, cyclic voltammetry, electrochemical impedance spectroscopy and Raman spectroscopy. The direct drawing of ePADs on sandpaper platforms through a graphite pencil has offered suitable repeatability (RSD = 1.0%) and reproducibility (RSD = 4.0%) using [Fe(CN)6]4- as redox probe. The proposed ePAD provided linear behaviour in the midazolam maleate concentration range between 2.5 and 150 mg L-1 and a limit of detection of 2.0 mg L-1. The feasibility of the ePAD for forensic application was successfully demonstrated through the detection of midazolam in different beverages (water, beer, liquor, and vodka). The intended application revealed low interference of other compounds present in beverages. Based on the achieved results, the proposed ePAD has offered great accuracy with no statistical difference at 95% confidence level from the data recorded by high performance liquid chromatography. The operational simplicity and the robustness ensured by the assembling on a reusable 3D printed holder make the ePAD drawn on sandpaper platform a powerful and promising analytical tool for the analysis of "date rape drugs" opening new possibilities for on-site forensic investigations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estupro / Preparações Farmacêuticas / Grafite Idioma: En Revista: Talanta Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estupro / Preparações Farmacêuticas / Grafite Idioma: En Revista: Talanta Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda