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Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment.
Dos Santos, Bruna E; Giacomini, Ana C V V; Marcon, Leticia; Demin, Konstantin A; Strekalova, Tatyana; de Abreu, Murilo S; Kalueff, Allan V.
Afiliação
  • Dos Santos BE; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Giacomini ACVV; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Marcon L; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Demin KA; Institute of Experimental Medicine, Almazov National Medcial Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Granov Russian Scientific Research Center of Radiology
  • Strekalova T; Department of Psychiatry and Neuropsychology, Maastricht University, Netherlands; Laboratory of Psychiatric Neurobiology, Sechenov 1st Moscow State Medical University, Moscow, Russia; Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
  • de Abreu MS; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic add
  • Kalueff AV; Granov Russian Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Scientific Research Institute of Neuroscience and Medicine, Novosibirsk, Russia; School of Pharmacy, Southwest University, Chongqing, China; Ural Fe
Neurosci Lett ; 759: 135993, 2021 08 10.
Article em En | MEDLINE | ID: mdl-34058290
Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-µM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying how both individual and sex differences shape behavioral and pharmacological responses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Escopolamina / Caracteres Sexuais / Antagonistas Colinérgicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Escopolamina / Caracteres Sexuais / Antagonistas Colinérgicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda