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Transcranial direct current stimulation (tDCS) has beneficial effects on liver lipid accumulation and hepatic inflammatory parameters in obese rats.
Longo, Larisse; de Souza, Valessa Emanoele Gabriel; Stein, Dirson João; de Freitas, Joice Soares; Uribe-Cruz, Carolina; Torres, Iraci L S; Álvares-da-Silva, Mário Reis.
Afiliação
  • Longo L; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. larisselongo@hotmail.com.
  • de Souza VEG; Experimental Laboratory of Hepatology and Gastroenterology, Center for Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. larisselongo@hotmail.com.
  • Stein DJ; Experimental Laboratory of Hepatology and Gastroenterology, Center for Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • de Freitas JS; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Center for Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • Uribe-Cruz C; Graduate Program in Medicine: Medical Sciences, Universidade Federal Rio Grande do Sul, Porto Alegre, Brazil.
  • Torres ILS; Laboratory of Pain Pharmacology and Neuromodulation: Preclinical Investigations, Center for Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • Álvares-da-Silva MR; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Sci Rep ; 11(1): 11037, 2021 05 26.
Article em En | MEDLINE | ID: mdl-34040131
Obesity is key to liver steatosis development and progression. Transcranial direct current stimulation (tDCS) is a promising tool for eating disorders management but was not yet evaluated in steatosis. This study investigated tDCS' effects on liver steatosis and inflammation in an experimental obesity model. Male Wistar rats (60 days-old) were randomly allocated (n = 10/group) as follows: standard-diet/sham tDCS (SDS), standard-diet/tDCS (SDT), hypercaloric-cafeteria-diet/sham tDCS (HDS), and hypercaloric-cafeteria-diet/tDCS (HDT). After 40 days of diet, animals received active or sham tDCS for eight days and were euthanized for liver fat deposition and inflammation analysis. HDS and HDT animals showed cumulative food consumption, total liver lipid deposits, IL-1ß, TNF-α levels, IL-1ß/IL-10 and TNF-α/IL-10 ratios significantly higher than the SDS and SDT groups (p < 0.001 for all parameters). tDCS (SDT and HDT) reduced liver lipid deposits (0.7 times for both, p < 0.05), IL-1ß (0.7 times and 0.9 times, respectively, p < 0.05) and IL-1ß/IL-10 index (0.6 times and 0.8 times, respectively, p < 0.05) in relation to sham (SDS and HDS). There was an interaction effect on the accumulation of hepatic triglycerides (p < 0.05). tDCS reduced 0.8 times the average liver triglyceride concentration in the HDT vs. HDS group (p < 0.05). In this obesity model, tDCS significantly decreased liver steatosis and hepatic inflammation. These results may justify looking into tDCS utility for human steatosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fígado Gorduroso / Estimulação Transcraniana por Corrente Contínua / Obesidade Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fígado Gorduroso / Estimulação Transcraniana por Corrente Contínua / Obesidade Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido