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In vivo effectiveness of hybrid membranes with osteogenic growth peptide for bone regeneration.
Oshiro-Junior, João Augusto; Barros, Rafaela Moreno; da Silva, Camila Garcia; de Souza, Caroline Cordeiro; Scardueli, Cássio Rocha; Marcantonio, Camila Chiérici; da Silva Saches, Paulo Ricardo; Mendes, Larissa; Cilli, Eduardo Maffud; Marcantonio, Rosemary Adriana Chierici; Chiavacci, Leila Aparecida.
Afiliação
  • Oshiro-Junior JA; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Bairro Universitário, Campina Grande, Paraíba, Brazil.
  • Barros RM; Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • da Silva CG; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Bairro Universitário, Campina Grande, Paraíba, Brazil.
  • de Souza CC; Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Scardueli CR; Faculty of Dentistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Marcantonio CC; Graduation Program in Pharmaceutical Sciences, State University of Paraíba, Bairro Universitário, Campina Grande, Paraíba, Brazil.
  • da Silva Saches PR; Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Mendes L; Faculty of Dentistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Cilli EM; Department of Biochemistry and Chemical Technology, Chemistry Institute, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Marcantonio RAC; Department of Biochemistry and Chemical Technology, Chemistry Institute, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
  • Chiavacci LA; Department of Biochemistry and Chemical Technology, Chemistry Institute, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
J Tissue Eng Regen Med ; 15(8): 722-731, 2021 08.
Article em En | MEDLINE | ID: mdl-34038031
Guided bone regeneration (GBR) technique helps to restore bone tissue through cellular selectivity principle. Currently no osteoinductive membrane exists on the market. Osteogenic growth peptide (OGP) acts as a hematopoietic stimulator. This association could improve the quality of bone formation, benefiting more than 2.2 million patients annually. The objective of this work was to develop membranes from ureasil-polyether materials containing OGP. The membranes were characterized by differential scanning calorimetry (DSC) and small angle X-ray scattering (SAXS). OGP was synthesized by the solid phase method. Sterilization results using gamma radiation at 24 kGy did not change the structure of the material, as confirmed by DSC. The SAXS technique revealed the structural homogeneity of the matrix. OGP was incorporated in 66.25 × 10-10  mol and release results showed that the ureasil-PPO400/PEO500 and ureasil-PPO400/PEO1900 membranes released 7% and 21%, respectively, after 48 h. In vivo results demonstrated that the amount and quality of bone tissue formed in the bone defects in the presence of ureasil-polyether membranes with OGP were similar to commercial collagen material with BMP. The results allow us to conclude that membranes with OGP have characteristics that make them potential candidates for the GBR.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração Óssea / Histonas / Peptídeos e Proteínas de Sinalização Intercelular / Regeneração Tecidual Guiada / Alicerces Teciduais Limite: Animals Idioma: En Revista: J Tissue Eng Regen Med Assunto da revista: BIOTECNOLOGIA / HISTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração Óssea / Histonas / Peptídeos e Proteínas de Sinalização Intercelular / Regeneração Tecidual Guiada / Alicerces Teciduais Limite: Animals Idioma: En Revista: J Tissue Eng Regen Med Assunto da revista: BIOTECNOLOGIA / HISTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido