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Phytochemical Analysis and Antinociceptive Properties of Hydroalcoholic Extracts of Aleurites moluccanus Bark.
de Souza, Márcia Maria; Chagas, Luiz G R D; Gonçalves, Ana Elisa; Tomczak, Marcelo; Reichert, Simone; Schuquel, Ivania T A; Cechinel-Filho, Valdir; Meyre-Silva, Christiane.
Afiliação
  • de Souza MM; Universidade do Vale do Itajaí (UNIVALI), Escola de Ciências da Saúde, Itajaí, Santa Catarina State, Brazil.
  • Chagas LGRD; Universidade do Vale do Itajaí (UNIVALI), Escola de Ciências da Saúde, Itajaí, Santa Catarina State, Brazil.
  • Gonçalves AE; Universidade do Vale do Itajaí (UNIVALI), Escola de Ciências da Saúde, Itajaí, Santa Catarina State, Brazil.
  • Tomczak M; Universidade do Vale do Itajaí (UNIVALI), Escola de Ciências da Saúde, Itajaí, Santa Catarina State, Brazil.
  • Reichert S; Universidade do Vale do Itajaí (UNIVALI), Escola de Ciências da Saúde, Itajaí, Santa Catarina State, Brazil.
  • Schuquel ITA; Universidade Estadual de Maringá (UEM), Departamento de Química, Maringá, Paraná State, Brazil.
  • Cechinel-Filho V; Universidade do Vale do Itajaí (UNIVALI), Escola de Ciências da Saúde, Itajaí, Santa Catarina State, Brazil.
  • Meyre-Silva C; Pós-graduação em Farmácia. Universidade Federal de Santa Catarina (UFSC), Bloco JK, Campus Reitor João David Ferreira Lima, Trindade, Florianópolis, Santa Catarina State, Brazil.
Planta Med ; 87(10-11): 896-906, 2021 Aug.
Article em En | MEDLINE | ID: mdl-34034350
Aleurites moluccanus is used in folk medicine to treat many diseases including pain and inflammatory processes in general. Considering the potential of the leaf extract, evidenced in a previous study, the present study investigates the antinociceptive and anti-inflammatory properties of the hydroethanolic extract of A. moluccanus bark and isolated compounds in animal models of pain. The antinociceptive and anti-inflammatory activities of A. moluccanus bark were evaluated through hyperalgesia induced by carrageenan, PGE2, cytokines, bradykinin, epinephrine, Freund's complete adjuvant, and lipopolysaccharide. Five compounds were isolated from the dichloromethane bark extract: acetyl aleuritolic acid, atraric acid, spruceanol, (5ß,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one and sonderianol. To optimize the extraction conditions, ethanol 50, 70, and 90°GL were used as extracting solvent, in a 1 : 20 (w/v) drug : solvent ratio, under stirring at room temperature for 4 h. The extracts were named AMC50, AMC70, and AMC90, respectively. These extracts were administered to mice (250 mg/kg, p. o.) with reduced mechanical hyperalgesia activity in the carrageenan test. Of these, AMC90 showed the best results. Pure (5ß,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one showed a beneficial effect for up to 48 hours after the administration of carrageenan, while acetyl aleuritolic acid was effective only in the first hour. AMC90 was able to reverse the analgesia induced only by prostaglandin E2 and tumor necrosis factor. We also induced hyperalgesia using the lipopolysaccharide and Freund's complete adjuvant models, with positive results. These results support the antinociceptive and anti-inflammatory activity of A. moluccanus bark extract. The observed effects are partly due to the presence of acetyl aleuritolic acid, atraric acid, and (5ß,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aleurites Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Planta Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aleurites Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Planta Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha