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Redox imbalance is related to HIV and pregnancy.
Martinez Manfio, Vanessa; Tasca, Karen Ingrid; Garcia, Jessica Leite; de Oliveira Góis, Janaina; Correa, Camila Renata; de Souza, Lenice do Rosário.
Afiliação
  • Martinez Manfio V; Department of Tropical Diseases- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
  • Tasca KI; Department of Microbiology and Immunology- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
  • Garcia JL; Department of Medical Clinics- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
  • de Oliveira Góis J; Department of Tropical Diseases- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
  • Correa CR; Department of Medical Clinics- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
  • de Souza LDR; Department of Tropical Diseases- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
PLoS One ; 16(5): e0251619, 2021.
Article em En | MEDLINE | ID: mdl-34019550
Redox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant women and non-pregnant were studied. Redox markers superoxide dismutase (SOD), catalase (CAT), protein carbonylation and malondialdehyde (MDA) were assessed at first or second trimester, third trimester and postpartum from pregnant and from non-pregnant women. According to the longitudinal analysis model, CAT activity was increased in the postpartum in HIV-positive women and before delivery in HIV-negative women. Increased carbonylation was observed in the pre-delivery period of HIV-negative pregnant women and MDA concentrations were higher in HIV-positive pregnant women compared to those non-infected by HIV at all times. According to the factorial model, higher SOD and CAT activities were observed in HIV-positive women in the initial months of pregnancy and in non-pregnant women. Carbonylation at third trimester was more evident in HIV-negative pregnant women. MDA levels were higher in HIV-positive pregnant women. Increased oxidative stress may occur in HIV-infected pregnant women. Nevertheless, the HIV virus is not solely responsible for this process; instead, mechanisms inherent to the pregnancy seem to play a role in this imbalance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Superóxido Dismutase / Catalase / Infecções por HIV / Carbonilação Proteica / Malondialdeído Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Pregnancy Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Superóxido Dismutase / Catalase / Infecções por HIV / Carbonilação Proteica / Malondialdeído Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Pregnancy Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos