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Phytochemical composition, antisnake venom and antibacterial activities of ethanolic extract of Aegiphila integrifolia (Jacq) Moldenke leaves.
Nascimento, Leandro S; Nogueira-Souza, Pâmella D; Rocha-Junior, José R S; Monteiro-Machado, Marcos; Strauch, Marcelo A; Prado, Simone A L; Melo, Paulo A; Veiga-Junior, Valdir F.
Afiliação
  • Nascimento LS; Chemical Engineering Section, Military Institute of Engineering, Rio de Janeiro, RJ, Brazil.
  • Nogueira-Souza PD; Federal University of Rio de Janeiro, Pharmacology and Medicinal Chemistry Program, Rio de Janeiro, RJ, Brazil.
  • Rocha-Junior JRS; Federal University of Rio de Janeiro, Pharmacology and Medicinal Chemistry Program, Rio de Janeiro, RJ, Brazil.
  • Monteiro-Machado M; Federal University of Rio de Janeiro, Pharmacology and Medicinal Chemistry Program, Rio de Janeiro, RJ, Brazil.
  • Strauch MA; Instituto Vital Brazil, Niterói, RJ, Brazil.
  • Prado SAL; Federal University of Roraima, Department of Chemistry, Boa Vista, RR, Brazil.
  • Melo PA; Federal University of Rio de Janeiro, Pharmacology and Medicinal Chemistry Program, Rio de Janeiro, RJ, Brazil.
  • Veiga-Junior VF; Chemical Engineering Section, Military Institute of Engineering, Rio de Janeiro, RJ, Brazil. Electronic address: valdir.veiga@gmail.com.
Toxicon ; 198: 121-131, 2021 Jul 30.
Article em En | MEDLINE | ID: mdl-33984369
Snakebites are considered a major neglected tropical disease, resulting in around 100,000 deaths per year. The recommended treatment by the WHO is serotherapy, which has limited effectiveness against the toxins involved in local tissue damage. In some countries, patients use plants from folk medicines as antivenoms. Aegiphila species are common plants from the Brazilian Amazon and are used to treat snakebites. In this study, leaves from Aegiphila integrifolia (Jacq) Moldenke were collected from Roraima state, Brazil and its ethanolic extract was evaluated through in vitro and in vivo experiments to verify their antiophidic activity against Bothrops atrox crude venom. The isolated compounds from A. integrifolia were analyzed and the chemical structures were elucidated on the basis of infrared, ultraviolet, mass, 1H and 1³C NMR spectrometry data. Among the described compounds, lupeol (7), betulinic acid (1), ß-sitosterol (6), stigmasterol (5), mannitol (4), and the flavonoids, pectolinarigenin (2) and hispidulin (3), were identified. The ethanolic extract and flavonoids (2 and 3) partially inhibited the proteolytic, phospholipase A2 and hyaluronidase activities of B. atrox venom, and the skin hemorrhage induced by this venom in mice. Antimicrobial activity against different bacteria was evaluated and the extract partially inhibited bacterial growth. Thus, taken together, A. integrifolia ethanolic extract has promising use as an antiophidic and antimicrobial.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mordeduras de Serpentes / Bothrops / Venenos de Crotalídeos / Anti-Infecciosos Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Toxicon Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mordeduras de Serpentes / Bothrops / Venenos de Crotalídeos / Anti-Infecciosos Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Toxicon Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido