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Assessment of carbamazepine acute toxicity in the cockle Cerastoderma edule through chemical, physiological and biochemical tools.
Jaouani, R; Dellali, M; Mouneyrac, C; Hassine, S Ben; Ali, M Ben; Hedfi, A; Hassan, M M; Beyrem, H; Boufahja, F.
Afiliação
  • Jaouani R; University of Carthage, Laboratory of Biomonitoring of the Environment LR01 ES14, Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia.
  • Dellali M; Laboratory 'Sea, Molecules, Health', Catholic University of the West, Angers, France.
  • Mouneyrac C; University of Carthage, Laboratory of Biomonitoring of the Environment LR01 ES14, Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia.
  • Hassine SB; Laboratory 'Sea, Molecules, Health', Catholic University of the West, Angers, France.
  • Ali MB; University of Carthage, Laboratory of Biomonitoring of the Environment LR01 ES14, Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia.
  • Hedfi A; Department of Biology, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
  • Hassan MM; University of Carthage, Laboratory of Biomonitoring of the Environment LR01 ES14, Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia.
  • Beyrem H; Department of Biology, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
  • Boufahja F; University of Carthage, Laboratory of Biomonitoring of the Environment LR01 ES14, Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia.
Braz J Biol ; 82: e247035, 2021.
Article em En | MEDLINE | ID: mdl-33978087
The cockle Cerastoderma edule was exposed to four concentrations (5, 10, 20 and 70 µg L-1) of carbamazepine (CBZ). This anticonvulsant was found to alter the mussel behavior of by reducing its clearance rate (CR). Analysis of CBZ accumulation in tissues of C. edule was carried out using HPLC-UV after 48 or 96 hours of exposure. In addition, an overproduction of H2O2 by the bivalves was detected following exposure to CBZ but nitrite levels remained unchanged. Moreover, superoxide dismutase and catalase activities showed a significant increase in relation to their contact with CBZ. The activity of the biotransformation enzyme gluthatione-S-transferase did not change during exposure. Malondialdehyde (MDA) levels indicating cellular damage, increased when bivalves were exposed to 20 and 70 µg l-1 of carbamazepine for 96 h CBZ. The results also indicate that acetylcholinesterase activity (AChE) was inhibited in all CBZ concentrations during the 48 h exposure period. However, during the 96 h exposure period, AChE was only inhibited at the highest concentration. Further studies are needed now for more exploration of the toxicity of CBZ since it could be bioaccumulable throughout the food web and may affect non-target organisms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Bivalves / Cardiidae Limite: Animals Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Tunísia País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Bivalves / Cardiidae Limite: Animals Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Tunísia País de publicação: Brasil