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Mortality among Hospitalized Dengue Patients with Comorbidities in Mexico, Brazil, and Colombia.
Macias, Alejandro E; Werneck, Guilherme L; Castro, Raúl; Mascareñas, Cesar; Coudeville, Laurent; Morley, David; Recamier, Vincent; Guergova-Kuras, Mariana; Etcheto, Adrien; Puentes-Rosas, Esteban; Baurin, Nicolas; Toh, Myew-Ling.
Afiliação
  • Macias AE; 1Área De Microbiología, Departamento De Medicina y Nutrición, Universidad de Guanajuato, Guanajuato, Mexico.
  • Werneck GL; 2Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Castro R; 3Los Andes University, Bogota, Colombia.
  • Mascareñas C; 4Sanofi Pasteur, Lyon, France.
  • Coudeville L; 4Sanofi Pasteur, Lyon, France.
  • Morley D; 5Ariana Pharmaceuticals, Paris, France.
  • Recamier V; 5Ariana Pharmaceuticals, Paris, France.
  • Guergova-Kuras M; 5Ariana Pharmaceuticals, Paris, France.
  • Etcheto A; 5Ariana Pharmaceuticals, Paris, France.
  • Puentes-Rosas E; 6Sanofi Pasteur, Mexico City, Mexico.
  • Baurin N; 4Sanofi Pasteur, Lyon, France.
  • Toh ML; 4Sanofi Pasteur, Lyon, France.
Am J Trop Med Hyg ; 105(1): 102-109, 2021 05 10.
Article em En | MEDLINE | ID: mdl-33970884
Dengue patients with comorbidities may be at higher risk of death. In this cross-sectional study, healthcare databases from Mexico (2008-2014), Brazil (2008-2015), and Colombia (2009-2017) were used to identify hospitalized dengue cases and their comorbidities. Case fatality rates (CFRs), relative risk, and odds ratios (OR) for in-hospital mortality were determined. Overall, 678,836 hospitalized dengue cases were identified: 68,194 from Mexico, 532,821 from Brazil, and 77,821 from Colombia. Of these, 35%, 5%, and 18% were severe dengue, respectively. Severe dengue and age ≥ 46 years were associated with increased risk of in-hospital mortality. Comorbidities were identified in 8%, 1%, and 4% of cases in Mexico, Brazil, and Colombia, respectively. Comorbidities increased hospitalized dengue CFRs 3- to 17-fold; CFRs were higher with comorbidities regardless of dengue severity or age. The odds of in-hospital mortality were significantly higher in those with pulmonary disorders (11.6 [95% CI 7.4-18.2], 12.7 [95% CI 9.3-17.5], and 8.0 [95% CI 4.9-13.1] in Mexico, Brazil, and Colombia, respectively), ischemic heart disease (23.0 [95% CI 6.6-79.6], 5.9 [95% CI 1.4-24.6], and 7.0 [95% CI 1.9-25.5]), and renal disease/failure (8.3 [95% CI 4.8-14.2], 8.0 [95% CI 4.5-14.4], and 9.3 [95% CI 3.1-28.0]) across the three countries; the odds of in-hospital mortality from dengue with comorbidities was at least equivalent or higher than severe dengue alone (4.5 [95% CI 3.4-6.1], 9.6 [95% CI 8.6-10.6], and 9.0 [95% CI 6.8-12.0). In conclusion, the risk of death because of dengue increases with comorbidities independently of age and/or disease severity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Urológicas / Doenças Cardiovasculares / Dengue / Diabetes Mellitus Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Middle aged País/Região como assunto: America do sul / Brasil / Colombia / Mexico Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Urológicas / Doenças Cardiovasculares / Dengue / Diabetes Mellitus Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Middle aged País/Região como assunto: America do sul / Brasil / Colombia / Mexico Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos