Candida glabrata produces a melanin-like pigment that protects against stress conditions encountered during parasitism.
Future Microbiol
; 16: 509-520, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33960816
Aim: Melanin is a pigment that can help fungi to cause disease. Fungi often produce melanin-like pigments in the presence of L-dihydroxyphenylalanine (L-DOPA), but this is poorly studied in Candida glabrata, a yeast species that can cause human disease. Methods & materials:C. glabrata was grown in minimal medium with or without L-DOPA supplementation and submitted to a chemical treatment to isolate melanin. Results:C. glabrata turned black when grown in the presence of L-DOPA, whereas cells grown without L-DOPA supplementation remained white. Several experiments demonstrated that the black pigment was melanin. Melanized C. glabrata cells were effectively protected from antifungal drugs, incubation at 42°C and killing by cells of the immune system. Conclusion: In the presence of L-DOPA, C. glabrata produces melanin, increases antifungal resistance and has enhanced survival in contact with immunologic defense cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candidíase
/
Candida glabrata
/
Melaninas
Limite:
Animals
Idioma:
En
Revista:
Future Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido