Your browser doesn't support javascript.
loading
Ceiba pentandra cellulose crosslinked with citric acid for drug release systems.
Peraza-Ku, Silvia Argelia; Escobar-Morales, Beatriz; Rodríguez-Fuentes, Nayeli; Cervantes-Uc, José Manuel; Uribe-Calderon, Jorge Alonso.
Afiliação
  • Peraza-Ku SA; Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130 X 32 y 34, Chuburná de Hidalgo, CP 97205, Merida, Yucatán, Mexico.
  • Escobar-Morales B; Unidad de Energía Renovable, Carretera Sierra Papacal- Chuburna Puerto, Km. 5, C.P. 97302, Sierra Papacal, Yucatan, Mexico.
  • Rodríguez-Fuentes N; Laboratorio de Biomateriales, Consejo Nacional de Ciencia y Tecnología, Calle 43 No. 130 X 32 y 34, Chuburná de Hidalgo, 97205, Merida, Yucatan, Mexico.
  • Cervantes-Uc JM; Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130 X 32 y 34, Chuburná de Hidalgo, CP 97205, Merida, Yucatán, Mexico.
  • Uribe-Calderon JA; Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130 X 32 y 34, Chuburná de Hidalgo, CP 97205, Merida, Yucatán, Mexico. Electronic address: Jorge.uribe@cicy.mx.
Carbohydr Res ; 504: 108334, 2021 Jun.
Article em En | MEDLINE | ID: mdl-33957461
An alternative for the production of drug delivery system is proposed based on the Ceiba pentandra milkweed. The kapok cellulose was chemically crosslinked with citric acid (CA) at different CA proportions, and loaded with chlorhexidine diacetate (CHX) at different concentrations. Cellulose crosslinking was followed with FTIR and XPS analysis, and the CHX loading was determined using elemental analysis. In vitro studies showed a burst release within the first 2-3 h and the drug release kinetics was described with several models. In addition, the crosslinked Ceiba pentandra fibers did not exhibit a cytotoxic effect on human dermic fibroblasts. Results indicate that the crosslinked Ceiba pentandra fibers are a feasible material for the production of systems for drug release applications.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceiba Idioma: En Revista: Carbohydr Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceiba Idioma: En Revista: Carbohydr Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Holanda