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The relationship of childhood trauma and DNA methylation of NMDA receptor genes in first-episode schizophrenia.
Loureiro, Camila M; Fachim, Helene A; Corsi-Zuelli, Fabiana; Shuhama, Rosana; Menezes, Paulo R; Dalton, Caroline F; Del-Ben, Cristina M; Reynolds, Gavin P; Louzada-Junior, Paulo.
Afiliação
  • Loureiro CM; Department of Internal Medicine, Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo, 14049 9002, Brazil.
  • Fachim HA; Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, S1 1WB3, UK.
  • Corsi-Zuelli F; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, 14049 9004, Brazil.
  • Shuhama R; Population Mental Health Center - NAP-SaMP, University of São Paulo, 01246 9035, Brazil.
  • Menezes PR; Department of Endocrinology & Metabolism, Salford Royal Foundation Trust, Salford, M6 8HD6, UK.
  • Dalton CF; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, 14049 9004, Brazil.
  • Del-Ben CM; Department of Neurosciences & Behaviour, Ribeirão Preto Medical School, University of São Paulo, 14049 9007, Brazil.
  • Reynolds GP; Population Mental Health Center - NAP-SaMP, University of São Paulo, 01246 9035, Brazil.
  • Louzada-Junior P; Department of Neurosciences & Behaviour, Ribeirão Preto Medical School, University of São Paulo, 14049 9007, Brazil.
Epigenomics ; 13(12): 927-937, 2021 06.
Article em En | MEDLINE | ID: mdl-33942662
Lay abstract Schizophrenia results from a combination of genetic and environmental influences. We investigated how some changes in genes can be silenced by a process named DNA methylation and may be linked to schizophrenia. For this reason, we hypothesized that childhood trauma, an environmental risk factor, would be associated with DNA methylation in schizophrenia patients compared with their unaffected siblings and controls. Our research has shown that altered blood DNA methylation of one candidate gene for psychiatric disorders may be associated with childhood trauma in the unaffected siblings of schizophrenia patients, but not in frank schizophrenia or controls. We believe that this gene plays an important role in helping identify vulnerable as well as resilient individuals to schizophrenia disorder.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Receptores de N-Metil-D-Aspartato / Suscetibilidade a Doenças / Experiências Adversas da Infância Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Epigenomics Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Receptores de N-Metil-D-Aspartato / Suscetibilidade a Doenças / Experiências Adversas da Infância Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Epigenomics Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido