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Informant-Reported Discrimination, Dementia, and Cognitive Impairment in Older Brazilians.
Farfel, Jose M; Barnes, Lisa L; Capuano, Ana; Sampaio, Maria Carolina de Moraes; Wilson, Robert S; Bennett, David A.
Afiliação
  • Farfel JM; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  • Barnes LL; Department of Pathology, Rush University Medical Center, Chicago, IL, USA.
  • Capuano A; Health Sciences Program, Instituto de Assistência Medica ao Servidor Público do Estado (IAMSPE), São Paulo, Brazil.
  • Sampaio MCM; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  • Wilson RS; Department of Neurological Sciences, Rush Medical College, Chicago, IL, USA.
  • Bennett DA; Department of Psychiatry and Behavioral Sciences, Rush Medical College, Chicago, IL, USA.
J Alzheimers Dis ; 84(3): 973-981, 2021.
Article em En | MEDLINE | ID: mdl-33935076
BACKGROUND: Self-reported discrimination is a source of psychosocial stress that has been previously associated with poor cognitive function in older African Americans without dementia. OBJECTIVE: Here, we examine the association of discrimination with dementia and cognitive impairment in racially diverse older Brazilians. METHODS: We included 899 participants 65 years or older (34.3% Black) from the Pathology, Alzheimer's and Related Dementias Study (PARDoS), a community-based study of aging and dementia. A structured interview with informants of the deceased was conducted. The interview included the Clinical Dementia Rating (CDR) Scale for the diagnosis of dementia and cognitive impairment proximate to death and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a second measure of cognitive impairment. Informant-reported discrimination was assessed using modified items from the Major and Everyday Discrimination Scales. RESULTS: Discrimination was reported by informants of 182 (20.2%) decedents and was more likely reported by informants of Blacks than Whites (25.3% versus 17.6%, p = 0.006). Using the CDR, a higher level of informant-reported discrimination was associated with higher odds of dementia (OR: 1.24, 95% CI 1.08 -1.42, p = 0.002) and cognitive impairment (OR: 1.21, 95% CI: 1.06 -1.39, p = 0.004). Similar results were observed using the IQCODE (estimate: 0.07, SE: 0.02, p = 0.003). The effects were independent of race, sex, education, socioeconomic status, major depression, neuroticism, or comorbidities. CONCLUSION: Higher level of informant-reported discrimination was associated with higher odds of dementia and cognitive impairment in racially diverse older Brazilians.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Família / Demência / Disfunção Cognitiva / Discriminação Social Tipo de estudo: Etiology_studies / Prognostic_studies / Qualitative_research Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Família / Demência / Disfunção Cognitiva / Discriminação Social Tipo de estudo: Etiology_studies / Prognostic_studies / Qualitative_research Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda