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Emergence of Antibiotic Resistance Across Two-Stage Revision for Periprosthetic Joint Infection.
Ludwick, Leanne; Chisari, Emanuele; Wang, Jasmine; Clarkson, Samuel; Collins, Lacee; Parvizi, Javad.
Afiliação
  • Ludwick L; Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.
  • Chisari E; Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.
  • Wang J; Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.
  • Clarkson S; Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.
  • Collins L; Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.
  • Parvizi J; Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.
J Arthroplasty ; 36(8): 2946-2950, 2021 08.
Article em En | MEDLINE | ID: mdl-33934949
BACKGROUND: The current preferred treatment for chronic hip and knee periprosthetic joint infection (PJI) involves both surgical intervention and antibiotic treatment as part of a two-stage revision. The purpose of this study is to determine how often patients who underwent a two-stage revision for chronic PJI developed a subsequent antibiotic-resistant infection. METHODS: We retrospectively reviewed the clinical records of 142 patients who underwent a two-stage revision for a chronic culture-positive PJI from January 2014 to May 2019. Demographic data and risk factors for PJI were identified. Resistance was defined in accordance with microbiology laboratory report and minimum inhibitory concentration. Statistical analysis consisted of descriptive statistics and univariate analysis. RESULTS: Only 10 of the 142 patients (7.04%) demonstrated emergence of resistance to antibiotics across their two-stage revision. At reimplantation, 25 (17.6%) patients had positive cultures. Of these, 16 patients presented with a novel organism and 9 patients had positive culture for the same organism as the initial infection. During the entire course of the two-stage revision, including spacer exchanges and irrigation and debridement procedures, 15 (10.56%) patients demonstrated persistent infections, whereas 25 (17.6%) patients presented with novel infections. 26 (18.3%) patients had reinfection of the same joint within one year. CONCLUSION: In the given cohort, there does not appear to be a major emergence of antibiotic resistant organisms in patients undergoing two-stage exchange arthroplasty and antibiotic treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Relacionadas à Prótese / Artroplastia de Quadril / Artroplastia do Joelho Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Arthroplasty Assunto da revista: ORTOPEDIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Relacionadas à Prótese / Artroplastia de Quadril / Artroplastia do Joelho Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Arthroplasty Assunto da revista: ORTOPEDIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos