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RANK, RANKL, and OPG in Dentigerous Cyst, Odontogenic Keratocyst, and Ameloblastoma: A Meta-Analysis.
Lima, Igor Felipe Pereira; Matos, Felipe Rodrigues de; Bernardino, Ítalo de Macedo; Santana, Ingrede Tatiane Serafim; Vieira, Walbert de Andrade; Blumenberg, Cauane; Siqueira, Walter Luiz; Paranhos, Luiz Renato.
Afiliação
  • Lima IFP; Department of Oral Pathology, School of Dentistry, UFRGS - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Matos FR; Departament of Dentistry, UFS - Universidade Federal de Sergipe, Lagarto, Sergipe, Brazil.
  • Bernardino ÍM; Department of Dentistry, UEPB - Universidade Federal da Paraíba, Campina Grande, PB, Brazil.
  • Santana ITS; Department of Nursing, Universidade Federal de Sergipe, Lagarto, SE, Brazil.
  • Vieira WA; Department of Restorative Dentistry, Endodontics Division, School of Dentistry of Piracicaba, UNICAMP - Universidade Estadual de Campinas, Piracicaba, SP, Brazil.
  • Blumenberg C; Department of Social Medicine, UFPEL - Universidade Federal de Pelotas, Pelotas, RS, Brazil.
  • Siqueira WL; College of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada.
  • Paranhos LR; Department of Preventive and Community Dentistry, UFU - Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
Braz Dent J ; 32(1): 16-25, 2021.
Article em En | MEDLINE | ID: mdl-33913997
The aim of this study was to assess and compare RANK, RANKL, and OPG immunoexpression in dentigerous cyst, odontogenic keratocyst, and ameloblastoma. The protocol was registered in PROSPERO (CRD42018105543). Seven databases (Embase, Lilacs, LIVIVO, PubMed, Scopus, SciELO, and Web of Science) were the primary search sources and two databases (Open Grey and Open Thesis) partially captured the "grey literature". Only cross sectional studies were included. The JBI Checklist assessed the risk of bias. A meta-analysis with random effects model estimated the values from the OPG and RANKL ratio reported by the individual studies and respective 95% confidence intervals. The heterogeneity among studies was assessed with I2 statistics. Only nine studies met the inclusion criteria and were considered in the analyses. The studies were published from 2008 to 2018. Two studies presented low risk of bias, while seven studies presented moderate risk. The meta-analysis showed the highest OPG>RANKL ratio for dentigerous cyst (ES=43.3%; 95% CI=14.3-74.8) and odontogenic keratocyst (ES=36.8%; 95% CI=18.8-56.7). In contrast, the highest OPG
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ameloblastoma / Cisto Dentígero / Cistos Odontogênicos / Tumores Odontogênicos Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Braz Dent J Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ameloblastoma / Cisto Dentígero / Cistos Odontogênicos / Tumores Odontogênicos Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Braz Dent J Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil