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Overview of miRNAs for the non-invasive diagnosis of endometriosis: evidence, challenges and strategies. A systematic review.
Monnaka, Vitor Ulisses; Hernandes, Camila; Heller, Debora; Podgaec, Sérgio.
Afiliação
  • Monnaka VU; Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
  • Hernandes C; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
  • Heller D; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
  • Podgaec S; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Einstein (Sao Paulo) ; 19: eRW5704, 2021.
Article em En, Pt | MEDLINE | ID: mdl-33909757
OBJECTIVE: The aim of the study was to assess the evidence on miRNAs as biomarkers for the diagnosis of endometriosis, as well as to provide insights into the challenges and strategies associated with the use of these molecules as accessible tools in clinical practice. METHODS: Systematic review conducted on PubMed®, Latin American and Caribbean Health Sciences Literature (LILACS), MEDLINE® and Web of Science databases using the search terms endometriosis (all fields) AND miRNA (all fields), evaluating all publication up to May 2019. RESULTS: Most miRNAs found to be dysregulated in this study were harvested from tissue samples, which precludes their use as a non-invasive diagnostic test. However, differential expression of 62 miRNAs was reported in samples that may be used for non-invasive diagnosis of endometriosis, such as blood, serum and plasma. CONCLUSION: Despite the identification of several candidates, studies are investigatory in nature and have been conducted with small number of samples. Also, no particular miRNA has been validated for diagnostic purposes so far. Studies based primarily on biological samples and applicable to translational research are warranted. Large databases comprising information on sample type and the use of saliva and vaginal fluid for miRNAs identification may prove essential to overcome current barriers to diagnosis of endometriosis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Endometriose Tipo de estudo: Diagnostic_studies / Overview / Prognostic_studies / Systematic_reviews Limite: Female / Humans Idioma: En / Pt Revista: Einstein (Sao Paulo) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Endometriose Tipo de estudo: Diagnostic_studies / Overview / Prognostic_studies / Systematic_reviews Limite: Female / Humans Idioma: En / Pt Revista: Einstein (Sao Paulo) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil