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Association of Righ-Risk Human Papillomavirus and Ureaplasma parvum Co-Infections with Increased Risk of Low-Grade Squamous Intraepithelial Cervical Lesions.
Noma, Isabella Harumi Yonehara; Shinobu-Mesquita, Cristiane Suemi; Suehiro, Tamy Taianne; Morelli, Fabricio; De Souza, Maria Vitória Felipe; Damke, Edilson; Da Silva, Vânia Ramos Sella; Consolaro, Marcia Edilaine Lopes.
Afiliação
  • Noma IHY; Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.
  • Shinobu-Mesquita CS; Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.
  • Suehiro TT; Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.
  • Morelli F; Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.
  • De Souza MVF; Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.
  • Damke E; Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.
  • Da Silva VRS; Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.
  • Consolaro MEL; Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.
Asian Pac J Cancer Prev ; 22(4): 1239-1246, 2021 Apr 01.
Article em En | MEDLINE | ID: mdl-33906318
OBJECTIVE: The present report investigated the rates of coinfections between high-rik human papillomavirus (hrHPV) and the most important human mycoplasmas including Mycoplasma hominis, M. genitalium, Ureaplasma urealyticum and U. parvum in cervical samples of asymptomatic brazilian population. METHODS: Were included a total of 283 women aged 25-64 years screened by Papanicolaou smears for determining cervical abnormalities, single-target polymerase chain reaction (PCR) and real-time PCR (rt-PCR) for hrHPV and mycoplasmas, respectively. RESULTS: A total of 273 (94.5%) women were negative for intraepithelial lesions or malignancy cytology (NILM) and 10 (3.5%) presented abnormal cytology, all low-grade intraepithelial lesions (LSIL). The prevalence of hrHPV was 12.7% and 53.7% for mycoplasmas. U. parvum was the most frequently bacteria detected, followed by Mycoplasma hominis and U. urealyticum. M. genitalium was not detected. Women positive for U. parvum presented a 5-fold increased risk of LSIL (OR = 5.33; 95% CI = 1.09-26.04, P = 0.02) and co-infections between U. parvum and hrHPV increased the risk for LSIL (OR = 3.88; 95% CI = 1.75-8.58, P = 0.0003). However, these associations were not dependent on the concentration of the bacteria. CONCLUSION: Our results reinforced the hypothesis that some mycoplasmas may play a role as cofactors in HPV-mediated cervical carcinogenesis, at least in some populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Ureaplasma / Infecções por Papillomavirus / Coinfecção / Lesões Intraepiteliais Escamosas Cervicais / Infecções por Mycoplasma Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Asian Pac J Cancer Prev Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Tailândia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Ureaplasma / Infecções por Papillomavirus / Coinfecção / Lesões Intraepiteliais Escamosas Cervicais / Infecções por Mycoplasma Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Asian Pac J Cancer Prev Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Tailândia