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Gestational Age, Birth Weight, and Neurocognitive Development in Adolescents in Tanzania.
Perumal, Nandita; Manji, Karim P; Darling, Anne Marie; Kisenge, Rodrick R; Kvestad, Ingrid; Hysing, Mari; Belinger, David C; Urassa, Willy; Strand, Tor A; Duggan, Christopher P; Fawzi, Wafaie W; Sudfeld, Christopher R.
Afiliação
  • Perumal N; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address: nperumal@hsph.harvard.edu.
  • Manji KP; Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Darling AM; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Kisenge RR; Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Kvestad I; Regional Center for Child and Youth Mental Health and Child Welfare, NORCE Norwegian Research Center, Bergen, Norway.
  • Hysing M; Department of Psychological Science, Faculty of Psychology, University of Bergen, Bergen, Norway.
  • Belinger DC; Department of Neurology, Boston Children's Hospital, Boston, MA.
  • Urassa W; Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Strand TA; Department of Research, Innlandet Hospital Trust, Lillehammer, Norway; Faculty of Medicine, Centre for International Health, University of Bergen, Bergen, Norway.
  • Duggan CP; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital and Harvard Medical School, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA
  • Fawzi WW; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Sudfeld CR; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
J Pediatr ; 236: 194-203.e6, 2021 Sep.
Article em En | MEDLINE | ID: mdl-33901518
OBJECTIVES: To investigate the association between gestational age, birthweight, and birthweight adjusted for gestational age, with domains of neurocognitive development and behavioral problems in adolescents in Tanzania. STUDY DESIGN: Data from a long-term follow-up of adolescents aged 11-15 years born to women previously enrolled in a randomized controlled trial of prenatal multiple micronutrient supplementation in Dar es Salaam, Tanzania, were used. A battery of neurodevelopmental tests were administered to measure adolescent general intelligence, executive function, and behavioral problems. The INTERGROWTH-21st newborn anthropometric standards were used to derive birthweight for gestational age z-scores. We assessed the shape of relationships using restricted cubic splines and estimated the associations of gestational age, birthweight, and birthweight for gestational age z-score with adolescent development using multivariable linear regressions. RESULTS: Among adolescents studied (n = 421), higher gestational age (per week), birthweight (per 100 grams), and birthweight for gestational age z-score (per SD) were linearly associated with higher intelligence score (adjusted standardized mean difference, 0.05 SD [95% CI, 0.01-0.09], 0.04 SD [95% CI, 0.02-0.06], and 0.09 SD [95% CI, 0.01-0.17], respectively). Birthweight and birthweight for gestational age z-score, but not gestational age, were also associated with improved executive function. Low birthweight (<2500 g) was associated with lower intelligence and executive function scores. Associations between birthweight and executive function were stronger among adolescents born to women with higher education. CONCLUSIONS: The duration of gestation and birthweight were positively associated with adolescent neurodevelopment in Tanzania. These findings suggest that interventions to improve birth outcomes may also benefit adolescent cognitive function.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Idade Gestacional / Desenvolvimento do Adolescente / Função Executiva / Transtornos do Neurodesenvolvimento / Inteligência Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Idade Gestacional / Desenvolvimento do Adolescente / Função Executiva / Transtornos do Neurodesenvolvimento / Inteligência Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos