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Neuroprotective Effects of Acrocomia aculeata Pulp Oil Microcapsules on Rats Subjected to Chronic Stress.
Jacobowski, Ana Cristina; Parisotto, Eduardo Benedetti; Aydos, Leonardo Recena; Serafim de Souza, Roberta; Viveros, Sandra; Colín-Gonzalez, Ana Laura; Silva, Iandara Schettert; Sanjinez-Argandoña, Eliana Janet; Wilhelm Filho, Danilo; Angel, Abel Santamaría-Del; Macedo, Maria Lígia Rodrigues.
Afiliação
  • Jacobowski AC; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
  • Parisotto EB; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
  • Aydos LR; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
  • Serafim de Souza R; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
  • Viveros S; Laboratory of Excitatory Amino Acids, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
  • Colín-Gonzalez AL; Laboratory of Excitatory Amino Acids, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
  • Silva IS; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
  • Sanjinez-Argandoña EJ; Faculty of Food Engineering, Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Wilhelm Filho D; Department of Ecology and Zoology, Biology Sciences Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
  • Angel AS; Laboratory of Excitatory Amino Acids, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
  • Macedo MLR; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
J Med Food ; 24(10): 1068-1075, 2021 Oct.
Article em En | MEDLINE | ID: mdl-33872073
Acrocomia aculeata fruits are rich in monounsaturated fatty acid, ß-carotene, tocopherol, and other antioxidant compounds. The aim of our study was to investigate and compare the protective effects of A. aculeata pulp oil and microencapsulated pulp oil on brain oxidative damage induced by chronic restraint stress (CRS) in rats (cortex, hippocampus, and striatum). Thirty-six Wistar rats were divided into six treatment groups: C, P, and M groups received 1 µL/g of body weight of distilled water, pulp oil, and pulp oil microcapsules by daily gavage, respectively. The SC, SP, and SM groups received 1 µL/g of body weight of distilled water, pulp oil, and pulp oil microcapsules by daily gavage, respectively, and were then subjected to uninterrupted 6 h of CRS. After 21 days of testing, the rats were euthanized and the brain tissue of the groups was removed for evaluation for oxidative damage markers and antioxidant enzymes. Endpoints of oxidative stress (OS) markers (lipid peroxidation, protein carbonylation, and reduced glutathione [GSH]) and antioxidant enzymes (superoxide dismutase and catalase) were evaluated. By imposing chronic stress on rats, pulp oil and microcapsules of pulp oil induced positive antioxidant responses, mainly by increasing the GSH content, increasing the ability of neural tissues to deal with inherent OS, thus protecting against neurodegenerative diseases. The administration of A. aculeata pulp oil and microencapsulated pulp oil made the reversal of the oxidant parameters, which may protect the brain tissue of rats altered by CRS. The Clinical Trial Registration number: n° 1.008/2018 CEUA/UFMS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Arecaceae Limite: Animals Idioma: En Revista: J Med Food Assunto da revista: CIENCIAS DA NUTRICAO / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Arecaceae Limite: Animals Idioma: En Revista: J Med Food Assunto da revista: CIENCIAS DA NUTRICAO / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos