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Effects of physical exercise combined with captopril or losartan on left ventricular hypertrophy of hypertensive rats.
Tomaz de Castro, Quênia Janaína; Araujo, Carolina Morais; Watai, Patrícia Yoshie; de Castro E Silva, Samara Stéfani; de Lima, Wanderson Geraldo; Becker, Lenice Kappes; Locatelli, Jamille; Guimarães, Homero Nogueira; Grabe-Guimarães, Andrea.
Afiliação
  • Tomaz de Castro QJ; Pharmaceutical Science Program (CiPharma), School of Pharmacy, Federal University of Ouro Preto, Minas Gerais, Brazil.
  • Araujo CM; Pharmaceutical Science Program (CiPharma), School of Pharmacy, Federal University of Ouro Preto, Minas Gerais, Brazil.
  • Watai PY; Pharmaceutical Science Program (CiPharma), School of Pharmacy, Federal University of Ouro Preto, Minas Gerais, Brazil.
  • de Castro E Silva SS; Pharmaceutical Science Program (CiPharma), School of Pharmacy, Federal University of Ouro Preto, Minas Gerais, Brazil.
  • de Lima WG; Department of Biological Sciences (DECBI), Federal University of Ouro Preto, Minas Gerais, Brazil.
  • Becker LK; Sports Center (CEDUFOP), Federal University of Ouro Preto, Minas Gerais, Brazil.
  • Locatelli J; Sports Center (CEDUFOP), Federal University of Ouro Preto, Minas Gerais, Brazil.
  • Guimarães HN; Department of Electrical Engineering, Federal University of Minas Gerais, Belo Horizonte,Minas Gerais, Brazil.
  • Grabe-Guimarães A; Pharmaceutical Science Program (CiPharma), School of Pharmacy, Federal University of Ouro Preto, Minas Gerais, Brazil.
Clin Exp Hypertens ; 43(6): 536-549, 2021 Aug 18.
Article em En | MEDLINE | ID: mdl-33870805
Background: Left ventricular hypertrophy (LVH) is an endpoint of hypertensive cardiac alterations. Renin-angiotensin-aldosterone system (RAAS) blockers are among the most effective on LVH regression. Physical exercise combined to antihypertensive drug contributes to arterial pressure (AP) control and LVH prevention. We evaluated the effects of physical exercise combined to captopril or losartan during eight weeks for spontaneously hypertensive rats (SHR) on some cardiac parameters.Methods: SHR (n=5-6 per group) were sedentary or trained 5 days a week in treadmill during 8 weeks; and they were treated with daily oral captopril (12.5, 25, or 50mg/kg), losartan (2.5, 5, or 10mg/kg), or vehicle. At the end, it was obtained systolic AP (SAP), electrocardiogram (ECG), and hearts metalloproteinase 2 (MMP-2) activity and histology.Results: Captopril 25 and 50 mg/kg, and losartan 10 mg/kg lowered SAP of sedentary and trained SHR. Losartan 5 mg/kg combined with physical exercise also lowered SAP. Combined with exercise, captopril 50 mg/kg lowered 13.6% of QT interval, 14.2% of QTc interval, and 22.8% of Tpeak-Tend compared to sedentary SHR. Losartan 5 and 10mg/kg lowered QT interval of sedentary and trained SHR. Losartan 2.5, 5 and 10mg/kg combined with physical exercise lowered respectively 25.4%, 24.8%, and 31.8% of MMP-2 activity. Losartan (10mg/kg) combined with exercise reduced cardiomyocyte diameter.Conclusion: These data support the hypothesis of physical exercise combined with RAAS blockers could improve the benefits on hypertensive LVH treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertrofia Ventricular Esquerda / Losartan / Hipertensão Limite: Animals Idioma: En Revista: Clin Exp Hypertens Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertrofia Ventricular Esquerda / Losartan / Hipertensão Limite: Animals Idioma: En Revista: Clin Exp Hypertens Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido