Your browser doesn't support javascript.
loading
Development, Reliability, and Testing of a New Rating Scale for Neonatal Encephalopathy.
Garcia-Alix, Alfredo; Arnaez, Juan; Arca, Gemma; Agut, Thais; Alarcon, Ana; Martín-Ancel, Ana; Girabent-Farres, Montserrat; Valverde, Eva; Benavente-Fernández, Isabel.
Afiliação
  • Garcia-Alix A; Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain; NeNe Foundation, Madrid, Spain. Electronic address: alfredoalix@gmail.com.
  • Arnaez J; NeNe Foundation, Madrid, Spain; Hospital Universitario de Burgos, Burgos, Spain.
  • Arca G; NeNe Foundation, Madrid, Spain; Hospital Clínic (Maternitat)-IDIBAPS, Barcelona, Spain.
  • Agut T; Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain; NeNe Foundation, Madrid, Spain.
  • Alarcon A; Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain.
  • Martín-Ancel A; Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain.
  • Girabent-Farres M; Department of Physioterapy, School of Health Sciences, TecnoCampus-Pompeu Fabra University, Mataró, Barcelona, Spain.
  • Valverde E; NeNe Foundation, Madrid, Spain; Hospital Universitario La Paz, Madrid, Spain.
  • Benavente-Fernández I; NeNe Foundation, Madrid, Spain; Hospital Puerta del Mar, Cadiz, Spain; Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cádiz, Spain.
J Pediatr ; 235: 83-91.e7, 2021 Aug.
Article em En | MEDLINE | ID: mdl-33857465
OBJECTIVE: To develop and test the Neonatal Encephalopathy-Rating Scale (NE-RS), a new rating scale to grade the severity of neonatal encephalopathy (NE) within the first 6 hours after birth. STUDY DESIGN: A 3-phase process was conducted: (1) design of a comprehensive scale that would be specific, sensitive, brief, and unsophisticated; (2) evaluation in a cohort of infants with neonatal encephalopathy and healthy controls; and (3) validation with brain magnetic resonance imaging findings and outcome at 2 years of age. RESULTS: We evaluated the NE-RS in 54 infants with NE and 28 healthy infants. The NE-RS had excellent internal consistency (Cronbach alpha coefficient: 0.93 [95% CI 0.86-0.94]) and reliability (intraclass correlation coefficient in the NE cohort 0.996 [95% CI 0.993-0.998; P < .001]). Alertness, posture, motor response, and spontaneous activity were the top discriminators for degrees of NE. The cut-off value for mild vs moderate NE was 8 points (area under the curve [AUC] 0.99, 95% CI 0.85-1.00) and for moderate vs severe NE, 30 points (AUC 0.93, 95% CI 0.81-0.99). The NE-RS was significantly correlated with the magnetic resonance imaging score (Spearman Rho 0.77, P < .001) and discriminated infants who had an adverse outcome (AUC 0.91, 95% CI 0.83-0.99, sensitivity 0.82, specificity 0.81, positive predictive value 0.87, negative predictive value 0.74). CONCLUSIONS: The NE-RS is reliable and performs well in reflecting the severity of NE within the first 6 hours after birth. This tool could be useful when assessing clinical criteria for therapeutic hypothermia in NE.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Encefalopatias / Doenças do Recém-Nascido Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Infant / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Encefalopatias / Doenças do Recém-Nascido Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Infant / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos