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Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease.
Longo, Aline; Veiga, Gabriel Barreto; Cousen, Maria Isabel Schiavon; Karpinski, Caroline; Schneider, Augusto; Weber, Bernardete; Bertoldi, Eduardo Gehling; Borges, Lucia Rota; Bertacco, Renata Torres Abib.
Afiliação
  • Longo A; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil, alinemlongo@hotmail.com.
  • Veiga GB; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
  • Cousen MIS; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
  • Karpinski C; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
  • Schneider A; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
  • Weber B; Instituto de Pesquisa - Hospital do Coração (IP - HCor), São Paulo, SP, Brasil.
  • Bertoldi EG; Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
  • Borges LR; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
  • Bertacco RTA; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brasil.
Arch Endocrinol Metab ; 65(6): 676-683, 2021 Nov 24.
Article em En | MEDLINE | ID: mdl-33844899
OBJECTIVE: Paraoxonase 1 (PON1) is an enzyme that has antioxidant potential, which confers a protective effect against the atherosclerotic process. However, studies associating genetics, dietary patterns and PON1 activity in individuals with cardiovascular disease (CVD) are scarce. Thus, the aim of the current study was to evaluate the influence of dietary factors on serum PON1 in CVD patients. METHODS: Cross-sectional, sub-study of the BALANCE Program Trial. All patients aged 45 years or older and had evidence of established atherosclerotic disease in the preceding 10 years. Body weight, height, waist circumference, blood pressure, lipid profile and fasting glucose were collected. Food intake was assessed with 24-h dietary recall. Data was analyzed using SAS University Edition and a P value ≤ 0.05 was considered statistically significant. Sample was divided into three groups, according to the PON1 T(-107)C genotype (CC, CT and TT) and serum PON1 activity (Low, Medium, High). RESULTS: There were no genotype differences for major factors. However, the systolic blood pressure was lower for CT individuals (p<0.05). Intake of cholesterol, saturated fatty acids (SFA) and monounsaturated fatty acids (MUFAS) was higher in patients with lower PON1 activity. Lipid ingestion tended to be higher in patients with lower PON1 activity (p=0.08). In the multivariate logistic regression model, SFA intake (P=0.03), genotype (P=0.09), gender (P=0.04), age (P=0.07) and carbohydrate intake (P=0.16) contributed the most to the serum PON1 activity. CONCLUSION: Based on these findings, nutritional guidance for these patients becomes essential, since dietary components interact with serum PON1 activity more than genotype.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Arildialquilfosfatase Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2021 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Arildialquilfosfatase Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2021 Tipo de documento: Article País de publicação: Brasil