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PGAM1 and TP53 mRNA levels in canine mammary carcinomas - Short communication.
Maués, Tábata; Oliveira, Táya Figueiredo de; El-Jaick, Kênia Balbi; Figueiredo, Agnes Marie Sá; Ferreira, Maria De Lourdes Gonçalves; Ferreira, Ana Maria Reis.
Afiliação
  • Maués T; 1Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil.
  • Oliveira TF; 1Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil.
  • El-Jaick KB; 2Department of Genetics and Molecular Biology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Figueiredo AMS; 3Department of Medical Microbiology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Ferreira MLG; 1Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil.
  • Ferreira AMR; 1Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil.
Acta Vet Hung ; 69(1): 50-54, 2021 04 10.
Article em En | MEDLINE | ID: mdl-33844639
TP53 and PGAM1 genes play a key role in glycolysis which is an essential metabolic pathway of cancer cells for obtaining energy. The purpose of this work was to evaluate PGAM1 and TP53 mRNA expressions in canine mammary carcinomas (CMC) and to correlate them with animal data and tumour histological features. None of the nine samples analysed revealed PGAM1 DNA sequence variations. PGAM1 and TP53 RNA expressions from 21 CMC were analysed using a one-step reverse transcription-PCR kit and its platform system. Most CMC samples had low levels of PGAM1 mRNA (71.5%) and normal expression of TP53 mRNA (95.2%). Our results suggest a different feature of the Warburg effect on canine mammary cancer cells compared to human cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Mamárias Animais / Proteína Supressora de Tumor p53 / Fosfoglicerato Mutase / Doenças do Cão Limite: Animals Idioma: En Revista: Acta Vet Hung Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Hungria
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Mamárias Animais / Proteína Supressora de Tumor p53 / Fosfoglicerato Mutase / Doenças do Cão Limite: Animals Idioma: En Revista: Acta Vet Hung Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Hungria