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Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples.
López, Rosario; Khan, Sabir; Wong, Ademar; Sotomayor, María Del Pilar Taboada; Picasso, Gino.
Afiliação
  • López R; Laboratory of Physical Chemistry Research, Faculty of Sciences, National University of Engineering, Lima, Peru.
  • Khan S; Laboratory of Physical Chemistry Research, Faculty of Sciences, National University of Engineering, Lima, Peru.
  • Wong A; Analytical Department, Chemistry Institute, State University of São Paulo (UNESP), Araraquara, Brazil.
  • Sotomayor MDPT; Analytical Department, Chemistry Institute, State University of São Paulo (UNESP), Araraquara, Brazil.
  • Picasso G; National Institute for Alternative Technologies of Detection, Toxicological Evaluation & Removal of Micropollutants and Radioactives (INCT-DATREM), Araraquara, Brazil.
Front Chem ; 9: 615602, 2021.
Article em En | MEDLINE | ID: mdl-33816435
This work describes an electrochemical sensor for the selective recognition and quantification of amoxicillin and a ß-lactam antibiotic in real samples. This sensor consists of a carbon paste electrode (CPE) modified with mag-MIP (magnetic molecularly imprinted polymer), which was prepared by precipitation method via free radical using acrylamide (AAm) as functional monomer, N,N'-methylenebisacrylamide (MBAA) as a crosslinker, and potassium persulfate (KPS) as initiator, to functionalized magnetic nanoparticles. The magnetic non-imprinted polymers (mag-NIP) were prepared using the same experimental procedure without analyte and used for the preparation of a CPE for comparative studies. The morphological, structural, and electrochemical characteristics of the nanostructured material were evaluated using Field emission gun scanning electron microscopy (FEG-SEM), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Vibrating sample magnetometry (VSM), X-ray diffraction (XRD), and voltammetric technique. Electrochemical experiments performed by square wave voltammetry show that the mag-MIP/CPE sensor had a better signal response compared to the non-imprinted polymer-modified electrode (mag-NIP/CPE). The sensor showed a linear range from 2.5 to 57 µmol L-1 of amoxicillin (r 2 = 0.9964), with a limit of detection and a limit of quantification of 0.75 and 2.48 µmol L-1, respectively. No significant interference in the electrochemical signal of amoxicillin was observed during the testing experiments in real samples (skimmed milk and river water). The proposed mag-MIP/CPE sensor could be used as a good alternative method to confront other techniques to determine amoxicillin in different samples.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Peru País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Peru País de publicação: Suíça