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Evaluation of Antibiotic Dissemination into the Environment and Untreated Animals, by Analysis of Oxytetracycline in Poultry Droppings and Litter.
Pokrant, Ekaterina; Yévenes, Karina; Trincado, Lina; Terraza, Gigliola; Galarce, Nicolás; Maddaleno, Aldo; Martín, Betty San; Lapierre, Lisette; Cornejo, Javiera.
Afiliação
  • Pokrant E; Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago CP 8820808, Chile.
  • Yévenes K; Programa de Doctorado en Ciencias Silvoagropecuarias y Veterinarias, Campus Sur Universidad de Chile, Santa Rosa 11315, La Pintana, Santiago CP 8820808, Chile.
  • Trincado L; Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago CP 8820808, Chile.
  • Terraza G; Programa de Doctorado en Ciencias Silvoagropecuarias y Veterinarias, Campus Sur Universidad de Chile, Santa Rosa 11315, La Pintana, Santiago CP 8820808, Chile.
  • Galarce N; Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago CP 8820808, Chile.
  • Maddaleno A; Programa de Doctorado en Ciencias Silvoagropecuarias y Veterinarias, Campus Sur Universidad de Chile, Santa Rosa 11315, La Pintana, Santiago CP 8820808, Chile.
  • Martín BS; Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago CP 8820808, Chile.
  • Lapierre L; Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago CP 8820808, Chile.
  • Cornejo J; Programa de Doctorado en Ciencias Silvoagropecuarias y Veterinarias, Campus Sur Universidad de Chile, Santa Rosa 11315, La Pintana, Santiago CP 8820808, Chile.
Animals (Basel) ; 11(3)2021 Mar 17.
Article em En | MEDLINE | ID: mdl-33802994
Oxytetracycline (OTC) is widely used in broiler chickens. During and after treatment a fraction of OTC is excreted in its original form and as its epimer, 4-epi-OTC in droppings. To address the transfer of OTC into the environment, we evaluated the dissemination of OTC and 4-epi-OTC from treated birds to the environment and sentinels, through the simultaneous analysis of broiler droppings and litter. Male broiler chickens were bred in controlled conditions. One group was treated by orogastric tube with 80 mg kg-1 of OTC and two groups received no treatment (sentinels). OTC+4-epi-OTC were analyzed and detected by a HPLC-MS/MS post the end of treatment. The highest concentrations of OTC+4-epi-OTC were detected in the droppings of treated birds 14-days following the end of treatment (2244.66 µg kg-1), and one day following the end of treatment in the litter (22,741.68 µg kg-1). Traces of OTC+4-epi-OTC were detected in the sentinels' droppings and litter (<12.2 µg kg-1). OTC+4-epi-OTC can be transferred from treated birds to the environment and to other untreated birds. The presence and persistence of OTC+4-epi-OTC in litter could contribute to the selection of resistant bacteria in the environment, increasing the potential hazard to public and animal health.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Animals (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Animals (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça