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Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use.
Dries, Larissa Selbach; Haefliger, Rochelli; Seibert, Bruna Sherer; de Lima, Angélica Gewehr; Cardoso, Caroline de Oliveira; Perassolo, Magda Susana.
Afiliação
  • Dries LS; Graduate Program on Toxicology and Analytical Toxicology, Feevale University, Novo Hamburgo, RS, Brazil.
  • Haefliger R; Graduated in Psychology, Feevale University, Novo Hamburgo, RS, Brazil.
  • Seibert BS; Graduated in Pharmacy, Feevale University, Novo Hamburgo, RS, Brazil.
  • de Lima AG; Graduated in Pharmacy, Feevale University, Novo Hamburgo, RS, Brazil.
  • Cardoso CO; Psychology Course, Feevale University, Novo Hamburgo, RS, Brazil.
  • Perassolo MS; Program on Toxicology and Analytical Toxicology, Feevale University, Novo Hamburgo, RS, Brazil.
J Pharm Pharmacol ; 74(4): 547-555, 2022 Apr 20.
Article em En | MEDLINE | ID: mdl-33793790
OBJECTIVES: To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months. METHODS: A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.7 years old) and 35 nonusers (NOU; 88.6 % female, 62 ± 8.7 years old). The cognitive ability was assessed through tests approaching attention, memory and executive functions. The vitamin B12 was dosage using a chemiluminescent immunoassay and oxidative stress analysis, based on the evaluation of malondialdehyde, enzymatic activity of extracellular superoxide dismutase, glutathione peroxidase, catalase and the ferric reducing antioxidant power in plasma. KEY FINDINGS: A significant increase of the ferric reducing antioxidant power [omeprazole users (OU) group = 1690 µM ± 441 and nonusers (NOU) group = 1308 ± 616; P value=0.002] and a decrease on glutathione peroxidase levels [OU group = 0.534 (0.27-10.63) and NOU group = 71.86 (14.36-173.1); P value=0.006] were found on omeprazole users group, as well as differences on cognitive performance, with impairments on executive functions, automatic and attentional processing. CONCLUSIONS: Long-term use of omeprazole is suggested to induce an oxidative stress condition, which causes neurotoxicity and cognitive decline.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Omeprazol / Antioxidantes Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Omeprazol / Antioxidantes Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido